2019
Revisions of Medicare reimbursement policy for ambulatory blood pressure monitoring and the role of qualitative analysis
Ash GI. Revisions of Medicare reimbursement policy for ambulatory blood pressure monitoring and the role of qualitative analysis. Journal Of Clinical Hypertension 2019, 21: 1810-1812. PMID: 31642575, PMCID: PMC8030408, DOI: 10.1111/jch.13715.Peer-Reviewed Original ResearchFURIN variant associations with postexercise hypotension are intensity and race dependent
Cilhoroz BT, Schifano ED, Panza GA, Ash GI, Corso L, Chen M, Deshpande V, Zaleski A, Farinatti P, Santos LP, Taylor BA, O'Neill RJ, Thompson PD, Pescatello LS. FURIN variant associations with postexercise hypotension are intensity and race dependent. Physiological Reports 2019, 7: e13952. PMID: 30706700, PMCID: PMC6356167, DOI: 10.14814/phy2.13952.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBicyclingBlack or African AmericanBlood PressureCase-Control StudiesExerciseFemaleFurinGenetic Association StudiesGenetic Predisposition to DiseaseHumansHypertensionHypotensionMaleMiddle AgedObesityPhenotypePolymorphism, Single NucleotideRisk FactorsTime FactorsWhite PeopleYoung AdultConceptsPostexercise hypotensionSystolic BPDiastolic BPBlood pressure responseAmbulatory BP monitorBlood pressure regulationModerate-intensity cyclingRace-dependent associationsObese blacksAerobic exerciseBP measurementsBP monitorIntensity cyclingAwake hoursMmHgPressure regulationMinor alleleMerit further explorationPressure responseHypotensionHypertensionP-valueReceptor processingMultiple testing
2017
Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension
Pescatello LS, Schifano ED, Ash GI, Panza GA, Corso LML, Chen M, Deshpande V, Zaleski A, Cilhoroz B, Farinatti P, Taylor BA, O'Neill RJ, Thompson PD. Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension. Physiological Reports 2017, 5: e13510. PMID: 29180482, PMCID: PMC5704084, DOI: 10.14814/phy2.13510.Peer-Reviewed Original ResearchConceptsPost-exercise hypotensionAmbulatory blood pressure responsesBlood pressure responseAmbulatory BP monitorObese African AmericansModerate-intensity exerciseModerate-intensity cyclingMultiple testing thresholdDiastolic BPAcute exerciseValidation cohortBP measurementsBP monitorIntensity exerciseVigorous intensityVariant genotypesIntensity cyclingMmHgTesting thresholdMinor alleleModerate intensityPressure responseHypotensionHypertensionAfrican AmericansThe antihypertensive effects of aerobic versus isometric handgrip resistance exercise
Ash GI, Taylor BA, Thompson PD, MacDonald HV, Lamberti L, Chen MH, Farinatti P, Kraemer WJ, Panza GA, Zaleski AL, Deshpande V, Ballard KD, Mujtaba M, White CM, Pescatello LS. The antihypertensive effects of aerobic versus isometric handgrip resistance exercise. Journal Of Hypertension 2017, 35: 291-299. PMID: 27861249, PMCID: PMC5713890, DOI: 10.1097/hjh.0000000000001176.Peer-Reviewed Original ResearchConceptsIHG trainingAntihypertensive effectBlood pressureAerobic exerciseResistance exerciseCarotid-femoral pulse wave velocityPulse wave velocity changesBP benefitPrimary exercise modalityAmbulatory BP monitorPulse wave velocityMiddle-aged adultsSubset of participantsAntihypertensive therapyAwake SBPIHG exerciseAcute exerciseExercise modalitiesAcute boutAerobic trainingBP monitorAwake hoursStudy participantsLimited evidenceSBP
2016
Deep‐targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans
Pescatello LS, Schifano ED, Ash GI, Panza GA, Lamberti L, Chen M, Deshpande V, Zaleski A, Farinatti P, Taylor BA, Thompson PD. Deep‐targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans. Physiological Reports 2016, 4: e12992. PMID: 27940662, PMCID: PMC5064144, DOI: 10.14814/phy2.12992.Peer-Reviewed Original ResearchConceptsMultiple testing thresholdADD1 variantsAngiotensin type 1 receptorAmbulatory blood pressure responsesTesting thresholdBlood pressure responseExon sequencingAmbulatory BP monitorModerate-intensity exerciseType 1 receptorModerate-intensity cyclingPostexercise hypotensionRenal variantDiastolic BPAcute exerciseValidation cohortBP measurementsBP monitorIntensity exerciseVigorous intensityAdducin geneVariant genotypesAldosterone synthaseIntensity cyclingCYP11B2 variantsEffects of aerobic exercise intensity on ambulatory blood pressure and vascular responses in resistant hypertension
Santos LP, Moraes RS, Vieira PJ, Ash GI, Waclawovsky G, Pescatello LS, Umpierre D. Effects of aerobic exercise intensity on ambulatory blood pressure and vascular responses in resistant hypertension. Journal Of Hypertension 2016, 34: 1317-1324. PMID: 27137175, DOI: 10.1097/hjh.0000000000000961.Peer-Reviewed Original ResearchConceptsForearm blood flowResistant hypertensionDiastolic pressureAmbulatory BPBlood flowExercise intensityPoor blood pressure controlAmbulatory systolic pressureDevice-based proceduresAcute hemodynamic effectsBlood pressure controlAmbulatory blood pressureVenous occlusion plethysmographyMaximal exercise testingModerate aerobic exerciseModerate intensityAerobic exercise intensityVascular resistanceExercise testingHemodynamic effectsOcclusion plethysmographyBlood pressureResistant patientsSystolic pressureReactive hyperemia
2015
The blood pressure response to acute and chronic aerobic exercise: A meta-analysis of candidate gene association studies
Bruneau ML, Johnson BT, Huedo-Medina TB, Larson KA, Ash GI, Pescatello LS. The blood pressure response to acute and chronic aerobic exercise: A meta-analysis of candidate gene association studies. Journal Of Science And Medicine In Sport 2015, 19: 424-431. PMID: 26122461, DOI: 10.1016/j.jsams.2015.05.009.Peer-Reviewed Original ResearchConceptsAngiotensinogen M235TChronic aerobic exerciseDiastolic blood pressureBlood pressure changesBlood pressurePost-exercise phaseAerobic exerciseM235TAmbulatory conditionsCandidate gene association studiesBlood pressure responseAerobic exercise interventionAerobic exercise trainingGene association studiesChanges of BPMaximum oxygen consumptionOnly genetic variantExercise interventionOverweight menExercise trainingAcute exercisePressure changesSample characteristicsSystematic searchAssociation studies
2013
The promises and challenges of the use of genomics in the prescription of exercise for hypertension: the 2013 update.
Ash GI, Eicher JD, Pescatello LS. The promises and challenges of the use of genomics in the prescription of exercise for hypertension: the 2013 update. Current Hypertension Reviews 2013, 9: 130-47. PMID: 23971695, DOI: 10.2174/15734021113099990010.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureExerciseExercise TherapyGenomicsHumansHypertensionPolymorphism, GeneticPrecision MedicineConceptsBP responseCardiovascular disease risk factorsMajor global public health problemGlobal public health problemControl of hypertensionDisease risk factorsEffectiveness of exercisePrescription of exercisePublic health problemExercise prescriptionRisk factorsHypertensionTherapeutic modalitiesAmerican CollegeConsiderable individual variabilityHealth problemsSports medicineAerobic activityModerate intensityNext-generation sequencingAssociation studiesSpecific genetic variantsSignificant proportionMost daysGenetic variantsReproducibility of ambulatory blood pressure changes from the initial values on two different days
Ash GI, Walker TJ, Olson KM, Stratton JH, Gómez AL, Kraemer WJ, Volek JS, Pescatello LS. Reproducibility of ambulatory blood pressure changes from the initial values on two different days. Clinics 2013, 68: 1509-1515. PMID: 24473508, PMCID: PMC3840371, DOI: 10.6061/clinics/2013(12)06.Peer-Reviewed Original ResearchConceptsAmbulatory BP changesAmbulatory BP monitorBP changesBlood pressureDay 1Day 2BP monitorAmbulatory blood pressure changesDiastolic BP changesNormal blood pressureAmbulatory blood pressureBlood pressure changesCardiovascular health outcomesAlerting reactionReproducibility of changesDifferent daysBP reactivityHealth outcomesHealthy adultsSame investigatorNext morningWomenMeasures analysisMenTotal sample
2012
Antihypertensive Effects of Exercise Among Those With Resistant Hypertension
Ash GI, MacDonald HV, Pescatello LS. Antihypertensive Effects of Exercise Among Those With Resistant Hypertension. Hypertension 2012, 61: e1. PMID: 23129696, DOI: 10.1161/hypertensionaha.111.00126.Peer-Reviewed Original Research