2021
Emergency department‐initiated buprenorphine protocols: A national evaluation
Guo CZ, D'Onofrio G, Fiellin DA, Edelman EJ, Hawk K, Herring A, McCormack R, Perrone J, Cowan E. Emergency department‐initiated buprenorphine protocols: A national evaluation. Journal Of The American College Of Emergency Physicians Open 2021, 2: e12606. PMID: 34877567, PMCID: PMC8630357, DOI: 10.1002/emp2.12606.Peer-Reviewed Original ResearchClinical Opiate Withdrawal ScaleEmergency departmentBUP initiationBUP doseCOWS scoresEmergency department-initiated buprenorphineTreatment-eligible patientsOpioid use disorderOpiate Withdrawal ScaleBUP administrationDischarge careBUP treatmentEvidence-based practiceWithdrawal symptomsNaloxone prescriptionsPatient outcomesWithdrawal ScaleBuprenorphineUse disordersClinician judgmentReal-world settingClinical diagnosisDiagnosis checklistDoseLimited data
2019
User-centred clinical decision support to implement emergency department-initiated buprenorphine for opioid use disorder: protocol for the pragmatic group randomised EMBED trial
Melnick ER, Jeffery MM, Dziura JD, Mao JA, Hess EP, Platts-Mills TF, Solad Y, Paek H, Martel S, Patel MD, Bankowski L, Lu C, Brandt C, D’Onofrio G. User-centred clinical decision support to implement emergency department-initiated buprenorphine for opioid use disorder: protocol for the pragmatic group randomised EMBED trial. BMJ Open 2019, 9: e028488. PMID: 31152039, PMCID: PMC6550013, DOI: 10.1136/bmjopen-2018-028488.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineCluster AnalysisDecision Support Systems, ClinicalEmergency Service, HospitalFemaleHumansMaleMiddle AgedMulticenter Studies as TopicNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicUnited StatesYoung AdultConceptsOpioid use disorderEmergency departmentSecondary outcomesUse disordersEmergency department-initiated buprenorphineWestern Institutional Review BoardData Safety Monitoring BoardIndependent study monitorsRates of cliniciansRoutine emergency careSafety monitoring boardInstitutional review boardClinical decision support systemClinician prescribingPragmatic clusterPatient characteristicsPeer-reviewed journalsClinical decision supportPrimary outcomeED cliniciansWithdrawal symptomsOngoing treatmentPatients' willingnessMonitoring boardBuprenorphine