2012
Sterile Inflammatory Response in Acute Pancreatitis
Hoque R, Malik AF, Gorelick F, Mehal WZ. Sterile Inflammatory Response in Acute Pancreatitis. Pancreas 2012, 41: 353-357. PMID: 22415665, PMCID: PMC3306133, DOI: 10.1097/mpa.0b013e3182321500.Peer-Reviewed Original ResearchConceptsDamage-associated molecular patternsSterile inflammatory responseAcute pancreatitisInterleukin-1βInflammatory responseExperimental pancreatitisNOD-like receptor protein 3High mobility group box protein 1Toll-like receptor 4Remote organ injuryReceptor protein 3Acinar cellsExperimental acute pancreatitisIL-1 receptorNovel therapeutic targetBox protein 1Necrotic acinar cellsDAMP receptorsShock protein 70Disease resolutionPancreatic injuryOrgan injuryInitial injuryIL-18Pharmacologic antagonism
2008
Molecular basis for pancreatitis
Thrower E, Husain S, Gorelick F. Molecular basis for pancreatitis. Current Opinion In Gastroenterology 2008, 24: 580-585. PMID: 19122498, PMCID: PMC3030809, DOI: 10.1097/mog.0b013e32830b10e6.Peer-Reviewed Original ResearchConceptsChronic pancreatitisAcute pancreatitisPain responseAnimal modelsToll-like receptor 4Transient receptor potential vanilloid subtype 1Specific neural receptorsSevere acute pancreatitisBasic science studiesChymotrypsin CShock protein 70Neural receptorsReceptor 4Chronic diseasesPancreatitisAlcohol abuseReceptor 2Subtype 1Potential treatmentPilot studyProtective mechanismAcinar cellsProtein 70Genetic factorsYear findings