2013
A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation
Bleichert F, Balasov M, Chesnokov I, Nogales E, Botchan MR, Berger JM. A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation. ELife 2013, 2: e00882. PMID: 24137536, PMCID: PMC3791464, DOI: 10.7554/elife.00882.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCongenital MicrotiaDrosophilaGrowth DisordersHumansMicrognathismMicroscopy, ElectronMutationOrigin Recognition ComplexPatellaConceptsOrigin recognition complexMetazoan origin recognition complexMeier-Gorlin syndrome mutationsORC functionMcm2-7 loadingC-terminal helixMeier-Gorlin syndromeReplisome formationUncharacterized domainYeast complexRecognition complexDNA replicationEnigmatic functionSubunit organizationProper recruitmentBioinformatics analysisChromosomal originC-terminusOrc6Biochemical studiesCertain subunitsMutationsComplex formationSubunitsGlobal architecture
2009
A Dimeric Structure for Archaeal Box C/D Small Ribonucleoproteins
Bleichert F, Gagnon KT, Brown BA, Maxwell ES, Leschziner AE, Unger VM, Baserga SJ. A Dimeric Structure for Archaeal Box C/D Small Ribonucleoproteins. Science 2009, 325: 1384-1387. PMID: 19745151, PMCID: PMC2975540, DOI: 10.1126/science.1176099.Peer-Reviewed Original ResearchConceptsBox C/D sRNPArchaeal box C/D sRNPsRibosomal RNASingle-particle electron microscopyTarget ribosomal RNAArchaeon Methanocaldococcus jannaschiiOptimal protein synthesisRibose methylationMethanocaldococcus jannaschiiSmall ribonucleoproteinRNA componentEnzymatic functionSRNPDimeric structureMutational analysisProtein componentsProtein synthesisMethylationBase pairingRNAEukaryotesSnoRNPsArchaeaJannaschiiRibonucleoprotein