A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation
Bleichert F, Balasov M, Chesnokov I, Nogales E, Botchan MR, Berger JM. A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation. ELife 2013, 2: e00882. PMID: 24137536, PMCID: PMC3791464, DOI: 10.7554/elife.00882.Peer-Reviewed Original ResearchConceptsOrigin recognition complexMetazoan origin recognition complexMeier-Gorlin syndrome mutationsORC functionMcm2-7 loadingC-terminal helixMeier-Gorlin syndromeReplisome formationUncharacterized domainYeast complexRecognition complexDNA replicationEnigmatic functionSubunit organizationProper recruitmentBioinformatics analysisChromosomal originC-terminusOrc6Biochemical studiesCertain subunitsMutationsComplex formationSubunitsGlobal architecture