2008
The Feasibility of Adjuvant Carboplatin and Docetaxel in Patients with Curatively Resected Non-small Cell Lung Cancer
Stinchcombe TE, Harper HD, Hensing TA, Moore DT, Crane JM, Atkins JN, Willard EM, Detterbeck FC, Socinski MA. The Feasibility of Adjuvant Carboplatin and Docetaxel in Patients with Curatively Resected Non-small Cell Lung Cancer. Journal Of Thoracic Oncology 2008, 3: 145-151. PMID: 18303435, DOI: 10.1097/jto.0b013e318160c5f1.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantDocetaxelDrug-Related Side Effects and Adverse ReactionsFeasibility StudiesFemaleHumansLung NeoplasmsMaleMiddle AgedPatient ComplianceSurvival AnalysisTaxoidsConceptsNon-small cell lung cancerCell lung cancerAdjuvant therapySupportive therapyChemotherapy complianceLung cancerAdequate exposureResected non-small cell lung cancerAdjuvant cisplatin-based chemotherapyMulticenter phase II trialMedian age 65 yearsCycles of therapyPrimary end pointAcceptable toxicity profileBetter functional statusPhase II trialCisplatin-based chemotherapyMajority of patientsSquamous cell carcinomaAge 65 yearsAdjuvant carboplatinCommon histologyII trialIntercurrent illnessActive therapy
2003
A Phase I Study of Gemcitabine and Docetaxel for Advanced Stage Solid Tumors
Poole ME, Bernard SA, Churchel MA, Weissler MC, Calvo B, Cance W, Ollila D, Koruda M, Behrns K, Detterbeck FC. A Phase I Study of Gemcitabine and Docetaxel for Advanced Stage Solid Tumors. Cancer Investigation 2003, 21: 350-354. PMID: 12901280, DOI: 10.1081/cnv-120018225.Peer-Reviewed Original ResearchConceptsDose-limiting toxicityDose of docetaxelPhase IDay 1Solid tumorsAdvanced-stage solid tumorsSignificant nonhematologic toxicityPhase II studyRefractory solid tumorsPhase I studiesM2 i.Nonhematologic toxicityStable diseaseStarting doseII studyPartial responseHypersensitivity reactionsI studiesGastric cancerPrimary siteGemcitabinePatientsDocetaxelDoseConstant dose