2021
Executive Summary Screening for Lung Cancer: Chest Guideline and Expert Panel Report
Mazzone PJ, Silvestri GA, Souter LH, Caverly TJ, Kanne JP, Katki HA, Wiener RS, Detterbeck FC. Executive Summary Screening for Lung Cancer: Chest Guideline and Expert Panel Report. CHEST Journal 2021, 160: 1959-1980. PMID: 34270965, PMCID: PMC8727851, DOI: 10.1016/j.chest.2021.07.003.Peer-Reviewed Original ResearchConceptsNational Lung Screening TrialLow-dose chest CTLung cancerCT screeningChest CTClinical questionsLow-dose CT screeningEvidence baseLow-dose chest CT screeningAdditional clinical questionsScreen-detected findingsScreening-eligible individualsGrading of RecommendationsChest CT screeningStandard of careImportant clinical questionsSystematic literature reviewExpert Panel ReportLow-dose CTCHEST GuidelineCessation interventionsCochrane LibraryGuideline publicationLiterature reviewConsensus statement
2018
Recommendations for the Appropriate Structure, Communication, and Investigation of Tobacco Harm Reduction Claims. An Official American Thoracic Society Policy Statement
Leone FT, Carlsen KH, Chooljian D, Crotty Alexander LE, Detterbeck FC, Eakin MN, Evers-Casey S, Farber HJ, Folan P, Kathuria H, Latzka K, McDermott S, McGrath-Morrow S, Moazed F, Munzer A, Neptune E, Pakhale S, Sachs DPL, Samet J, Sufian B, Upson D. Recommendations for the Appropriate Structure, Communication, and Investigation of Tobacco Harm Reduction Claims. An Official American Thoracic Society Policy Statement. American Journal Of Respiratory And Critical Care Medicine 2018, 198: e90-e105. PMID: 30320525, PMCID: PMC6943880, DOI: 10.1164/rccm.201808-1443st.Peer-Reviewed Original Research
2013
Screening for Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Detterbeck FC, Mazzone PJ, Naidich DP, Bach PB. Screening for Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. CHEST Journal 2013, 143: e78s-e92s. PMID: 23649455, PMCID: PMC3749713, DOI: 10.1378/chest.12-2350.Peer-Reviewed Original ResearchConceptsLung cancer deathsLung cancerCancer deathChest Physicians Evidence-Based Clinical Practice GuidelinesEvidence-based clinical practice guidelinesLow-dose CT screeningMajority of patientsRisk of complicationsClinical practice guidelinesLung cancer diagnosisSignificant reductionNumber of deathsLDCT screeningCurative treatmentLarge RCTsCT screeningTreatment recommendationsChest radiographsPractice guidelinesAmerican CollegeEffective treatmentElevated riskResult of screeningAdvanced stageSystematic review
2006
Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells
Yim HW, Slebos RJ, Randell SH, Umbach DM, Parsons AM, Rivera MP, Detterbeck FC, Taylor JA. Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells. Cancer Letters 2006, 246: 24-33. PMID: 16517060, DOI: 10.1016/j.canlet.2006.01.023.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBronchiCell Culture TechniquesCell ProliferationCells, CulturedCellular SenescenceChildDNA MethylationEpithelial CellsFemaleHumansLung NeoplasmsMaleMiddle AgedPolymerase Chain ReactionPromoter Regions, GeneticSmokingTelomeraseTime FactorsTumor Cells, CulturedConceptsNormal bronchial epitheliumTelomeric repeat amplification protocolHuman bronchial epithelial cellsBronchial epithelial cellsBronchial epitheliumTelomerase activityLung cancer historyLung cancer statusEpithelial cellsMaximum passage numberTobacco carcinogen exposureHBE cell culturesRepeat amplification protocolExtended culturingHTERT promoterShort-term cultureSmoking historyTobacco smokingPassage numberCancer historyLung carcinogenesisLung carcinomaCancer statusCarcinogen exposureCausative role
2005
Chromosomal abnormalities in bronchial epithelium from smokers, nonsmokers, and lung cancer patients
Slebos RJ, Livanos E, Yim HW, Randell SH, Parsons AM, Detterbeck FC, Rivera MP, Taylor JA. Chromosomal abnormalities in bronchial epithelium from smokers, nonsmokers, and lung cancer patients. Cancer Genetics 2005, 159: 137-142. PMID: 15899385, DOI: 10.1016/j.cancergencyto.2004.10.008.Peer-Reviewed Original ResearchConceptsLung cancer patientsCancer patientsNon-lung cancer patientsAbnormal metaphasesChromosomal abnormalitiesHistory of smokingTobacco smoke exposureBronchial epithelial cell culturesHBE cell culturesCell culturesHuman bronchial epithelial cell culturesTobacco smokingSmoke exposureLung cancerEarly treatmentBronchial epitheliumCancer riskIdentification of individualsEpithelial cell culturesPatientsNonsmokersUseful markerGreater riskSmokersObserved abnormalities