2021
Screening for Lung Cancer CHEST Guideline and Expert Panel Report
Mazzone PJ, Silvestri GA, Souter LH, Caverly TJ, Kanne JP, Katki HA, Wiener RS, Detterbeck FC. Screening for Lung Cancer CHEST Guideline and Expert Panel Report. CHEST Journal 2021, 160: e427-e494. PMID: 34270968, PMCID: PMC8727886, DOI: 10.1016/j.chest.2021.06.063.Peer-Reviewed Original ResearchConceptsNational Lung Screening TrialLow-dose chest CTLung cancerCT screeningChest CTClinical questionsLow-dose CT screeningEvidence baseLow-dose chest CT screeningAdditional clinical questionsScreen-detected findingsScreening-eligible individualsGrading of RecommendationsChest CT screeningStandard of careImportant clinical questionsSystematic literature reviewExpert Panel ReportLow-dose CTCHEST GuidelineCessation interventionsCochrane LibraryGuideline publicationLiterature reviewConsensus statementExecutive Summary Screening for Lung Cancer: Chest Guideline and Expert Panel Report
Mazzone PJ, Silvestri GA, Souter LH, Caverly TJ, Kanne JP, Katki HA, Wiener RS, Detterbeck FC. Executive Summary Screening for Lung Cancer: Chest Guideline and Expert Panel Report. CHEST Journal 2021, 160: 1959-1980. PMID: 34270965, PMCID: PMC8727851, DOI: 10.1016/j.chest.2021.07.003.Peer-Reviewed Original ResearchConceptsNational Lung Screening TrialLow-dose chest CTLung cancerCT screeningChest CTClinical questionsLow-dose CT screeningEvidence baseLow-dose chest CT screeningAdditional clinical questionsScreen-detected findingsScreening-eligible individualsGrading of RecommendationsChest CT screeningStandard of careImportant clinical questionsSystematic literature reviewExpert Panel ReportLow-dose CTCHEST GuidelineCessation interventionsCochrane LibraryGuideline publicationLiterature reviewConsensus statement
2018
Screening for Lung Cancer CHEST Guideline and Expert Panel Report
Mazzone PJ, Silvestri GA, Patel S, Kanne JP, Kinsinger LS, Wiener RS, Hoo G, Detterbeck FC. Screening for Lung Cancer CHEST Guideline and Expert Panel Report. CHEST Journal 2018, 153: 954-985. PMID: 29374513, DOI: 10.1016/j.chest.2018.01.016.Peer-Reviewed Original ResearchConceptsLow-dose CT screeningLow-dose chest CTCT screeningChest CTClinical questionsNational Lung Screening TrialEvidence baseScreen-detected findingsLung cancer resultsChest CT screeningScreening-eligible patientsKey clinical questionsStandard of careImportant clinical questionsSystematic literature reviewExpert Panel ReportLow-dose CTCHEST GuidelineGRADE approachCessation interventionsCochrane LibraryLiterature reviewLung cancerPICO questionScreening Trial
2016
The differential impact of preoperative comorbidity on perioperative outcomes following thoracoscopic and open lobectomies
Jawitz OK, Wang Z, Boffa DJ, Detterbeck FC, Blasberg JD, Kim AW. The differential impact of preoperative comorbidity on perioperative outcomes following thoracoscopic and open lobectomies. European Journal Of Cardio-Thoracic Surgery 2016, 51: 169-174. PMID: 27458143, DOI: 10.1093/ejcts/ezw239.Peer-Reviewed Original ResearchConceptsNationwide Inpatient SampleOpen lobectomyPostoperative lengthVATS lobectomyLobectomy patientsVideo-assisted thoracoscopic surgery lobectomyBenign lung conditionsOpen lobectomy patientsPerioperative pulmonary complicationsVATS lobectomy patientsNumber of comorbiditiesNon-elective admissionsCell lung cancerMultivariable logistic regressionThoracoscopic surgery lobectomyStandard of careUtilization Project databasePreoperative patient comorbiditiesCumulative incidence modelsLogistic regression modellingHospital mortalityPreoperative comorbiditiesPulmonary complicationsGreater comorbidityPerioperative outcomes
2014
Predictors of Mortality After Surgical Management of Lung Cancer in the National Cancer Database
Rosen JE, Hancock JG, Kim AW, Detterbeck FC, Boffa DJ. Predictors of Mortality After Surgical Management of Lung Cancer in the National Cancer Database. The Annals Of Thoracic Surgery 2014, 98: 1953-1960. PMID: 25443003, DOI: 10.1016/j.athoracsur.2014.07.007.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerNational Cancer DatabaseLobectomy/bilobectomyAdverse eventsSurgical resectionMultivariable analysisMale sexFacility volumeLung cancerCancer DatabaseLung cancer surgeryPredictors of mortalityRight-sided tumorsDay of surgeryCell lung cancerStandard of careExtended lengthLarge cancer registryPerioperative outcomesPrimary endpointNSCLC patientsSurgical complicationsWedge resectionSurgical treatmentCancer RegistryFewer complications result from a video-assisted approach to anatomic resection of clinical stage I lung cancer
Boffa DJ, Dhamija A, Kosinski AS, Kim AW, Detterbeck FC, Mitchell JD, Onaitis MW, Paul S. Fewer complications result from a video-assisted approach to anatomic resection of clinical stage I lung cancer. Journal Of Thoracic And Cardiovascular Surgery 2014, 148: 637-643. PMID: 24529729, DOI: 10.1016/j.jtcvs.2013.12.045.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overFemaleHumansLogistic ModelsLung NeoplasmsMaleMiddle AgedMultivariate AnalysisNeoplasm StagingOdds RatioPneumonectomyPostoperative ComplicationsPropensity ScoreRisk FactorsThoracic Surgery, Video-AssistedThoracotomyTime FactorsTreatment OutcomeYoung AdultConceptsStage I lung cancerClinical stage I lung cancerI lung cancerThoracic Surgeons databaseAnatomic resectionLung cancerSurgeons databaseStage I primary lung cancerVideo-assisted thoracic surgery approachEarly-stage lung cancerMore pulmonary complicationsClinical stage ILung cancer resectionPrimary lung cancerMorbidity of patientsThoracic surgery approachStage lung cancerStandard of careMorbidity of thoracotomyVideo-assisted approachLower mortality rateOverall complicationsPulmonary complicationsThoracotomy groupVATS cohort
2007
Helical Computed Tomography Inaccuracy in the Detection of Pulmonary Metastases: Can It Be Improved?
Parsons AM, Ennis EK, Yankaskas BC, Parker LA, Hyslop WB, Detterbeck FC. Helical Computed Tomography Inaccuracy in the Detection of Pulmonary Metastases: Can It Be Improved? The Annals Of Thoracic Surgery 2007, 84: 1830-1836. PMID: 18036893, DOI: 10.1016/j.athoracsur.2007.06.069.Peer-Reviewed Original ResearchConceptsPulmonary metastasesLung palpationPulmonary metastasectomyHelical CTClinical historyPreoperative CTRadiologist 1Radiologist 2Preoperative CT scanningStandard of carePreoperative CT scanAdequate clinical historyChart reviewPulmonary lesionsThoracic surgeryPostoperative CTCT scanScan interpretationMetastasisCT scanningChest radiologistsTomography imagingCTPalpationMetastasectomy
2003
Gemcitabine-Based Combinations as Preoperative Therapy in Resectable Non–Small-Cell Lung Cancer
Socinski MA, Rivera MP, Detterbeck FC. Gemcitabine-Based Combinations as Preoperative Therapy in Resectable Non–Small-Cell Lung Cancer. Clinical Lung Cancer 2003, 4: s50-s55. PMID: 14720337, DOI: 10.3816/clc.2003.s.004.Peer-Reviewed Original ResearchGemcitabine-containing regimensPhase III trialsStage III NSCLCComplete surgical resectionPreoperative therapyIII trialsSurgical resectionInduction therapyLung cancerResectable non-small cell lung cancerNon-small cell lung cancerDominant recurrence patternGemcitabine-based combinationsSystemic micrometastatic diseaseCisplatin/gemcitabinePhase II trialMajority of patientsMinority of patientsCell lung cancerOverall response rateStandard of careAdjuvant chemotherapyAdvanced NSCLCII trialStage IB