2013
A New Method to Predict Postoperative Lung Function: Quantitative Breath Sound Measurements
Detterbeck F, Gat M, Miller D, Force S, Chin C, Fernando H, Sonett J, Morice R. A New Method to Predict Postoperative Lung Function: Quantitative Breath Sound Measurements. The Annals Of Thoracic Surgery 2013, 95: 968-975. PMID: 23369350, DOI: 10.1016/j.athoracsur.2012.07.045.Peer-Reviewed Original ResearchConceptsPostoperative lung functionVibration response imagingLung functionLung resectionPPO valuesPostoperative pulmonary function testsPulmonary function testsRate of complicationsSingle-center studyCategorization of patientsPerfusion measurementsActual postoperative valuesRadiation-free methodRadiation-free alternativeLung malignancyLung scintigraphyFunction testsPostoperative valuesPatient assessmentRegional perfusionElevated riskPatientsLungPerfusion methodPerfusion
2012
Stereotactic Body Radiotherapy for Central Lung Tumors
Rowe BP, Boffa DJ, Wilson LD, Kim AW, Detterbeck FC, Decker RH. Stereotactic Body Radiotherapy for Central Lung Tumors. Journal Of Thoracic Oncology 2012, 7: 1394-1399. PMID: 22843088, DOI: 10.1097/jto.0b013e3182614bf3.Peer-Reviewed Original ResearchConceptsStereotactic body radiotherapyCentral lung tumorsBiological equivalent doseLocal recurrenceTracheobronchial treeLung tumorsBody radiotherapyCentral lesionsEquivalent doseGrade 3Baseline pulmonary function testsLarger maximum tumor diameterMedian biological equivalent doseChest wall painGrade 3 dyspneaYale Cancer CenterGrade 2 toxicityLocal control ratePrimary lung cancerPulmonary function testsHigh-grade toxicityMajority of patientsVolume of lungMaximum tumor diameterMaximum point dose
2009
Impact of Preoperative Chemotherapy on Pulmonary Function Tests in Resectable Early-Stage Non-small Cell Lung Cancer
Rivera MP, Detterbeck FC, Socinski MA, Moore DT, Edelman MJ, Jahan TM, Ansari RH, Luketich JD, Peng G, Monberg M, Obasaju CK, Gralla RJ. Impact of Preoperative Chemotherapy on Pulmonary Function Tests in Resectable Early-Stage Non-small Cell Lung Cancer. CHEST Journal 2009, 135: 1588-1595. PMID: 19188545, DOI: 10.1378/chest.08-1430.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantCisplatinConfidence IntervalsDeoxycytidineDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesGemcitabineHumansLung NeoplasmsMaleMaximum Tolerated DoseMiddle AgedNeoadjuvant TherapyNeoplasm StagingPaclitaxelPneumonectomyPreoperative CareProbabilityRespiratory Function TestsRisk AssessmentSurvival AnalysisConceptsNon-small cell lung cancerCell lung cancerSurgical resectionLung cancerPulmonary toxicityResectable early stage non-small cell lung cancerEarly-stage non-small cell lung cancerRandomized phase 2 trialPulmonary function test resultsSecondary end pointsCombination of gemcitabinePhase 2 trialPulmonary function testsGemcitabine-based chemotherapyFunction test resultsTotal lung capacityEligible patientsNonplatinum regimensDyspnea scoreInterstitial pneumonitisPreoperative chemotherapyFunction testsSmoking statusClinical symptomsPreoperative setting