2015
Evaluating the fate of patients who undergo resections of very large, node-negative lung cancers using the National Cancer DataBase
Liu J, Hancock JG, Moreno AC, Wang Z, Boffa DJ, Detterbeck FC, Kim AW. Evaluating the fate of patients who undergo resections of very large, node-negative lung cancers using the National Cancer DataBase. European Journal Of Cardio-Thoracic Surgery 2015, 49: 596-601. PMID: 25890936, DOI: 10.1093/ejcts/ezv139.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellChemoradiotherapy, AdjuvantDatabases, FactualFemaleFollow-Up StudiesHumansLung NeoplasmsLymph NodesMaleMiddle AgedNeoadjuvant TherapyNeoplasm StagingPneumonectomyRetrospective StudiesSurvival AnalysisTreatment OutcomeTumor BurdenUnited StatesConceptsPostoperative radiation therapyNational Cancer DatabaseNeoadjuvant chemoradiation therapyAdjuvant chemoradiation therapyChemoradiation therapyAdjuvant chemotherapyOverall survivalSurgical therapyLung cancerCancer DatabaseNode-negative lung cancerImproved OS relativeLymph node involvementKaplan-Meier methodCell lung cancerCox regression modelFate of patientsLog-rank testDifferent treatment modalitiesOS relativeNode involvementMetastatic diseaseSurgical resectionLymph nodesOS ratesBolstering the Case for Lobectomy in Stages I, II, and IIIA Small-Cell Lung Cancer Using the National Cancer Data Base
Combs SE, Hancock JG, Boffa DJ, Decker RH, Detterbeck FC, Kim AW. Bolstering the Case for Lobectomy in Stages I, II, and IIIA Small-Cell Lung Cancer Using the National Cancer Data Base. Journal Of Thoracic Oncology 2015, 10: 316-323. PMID: 25319182, DOI: 10.1097/jto.0000000000000402.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerNational Cancer Data BaseSurgical resectionStage ISCLC patientsSublobar resectionOverall survivalLung cancerIIIA small cell lung cancerFive-year overall survivalAddition of surgeryClinical stage IPatient underwent surgeryPrimary surgical resectionKaplan-Meier methodLikelihood of deathCurative intentComorbidity scoreUnderwent surgeryChemoradiation therapyHazard ratioMetastatic diseaseMultimodality treatmentSelect patientsTreatment regimen
2013
Methods for Staging Non-small Cell Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Silvestri GA, Gonzalez AV, Jantz MA, Margolis ML, Gould MK, Tanoue LT, Harris LJ, Detterbeck FC. Methods for Staging Non-small Cell Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. CHEST Journal 2013, 143: e211s-e250s. PMID: 23649440, DOI: 10.1378/chest.12-2355.Peer-Reviewed Original ResearchConceptsLung cancerPET scanningNeedle techniqueCT scanningMediastinal metastasesMetastatic diseasePractice guidelinesAmerican CollegeChest Physicians Evidence-Based Clinical Practice GuidelinesTissue biopsiesChest Physicians Lung Cancer GuidelinesEvidence-based clinical practice guidelinesNon-small cell lung cancer diagnosisNon-small cell lung cancerMediastinal lymph node metastasisCell lung cancer diagnosisLung cancer guidelinesPET scan findingsLymph node metastasisCell lung cancerClinical practice guidelinesLymph node stationsUnsuspected metastatic diseaseEndobronchial ultrasound needle aspirationPET-CT scanning
2007
Noninvasive Staging of Non-small Cell Lung Cancer ACCP Evidenced-Based Clinical Practice Guidelines (2nd Edition)
Silvestri GA, Gould MK, Margolis ML, Tanoue LT, McCrory D, Toloza E, Detterbeck F. Noninvasive Staging of Non-small Cell Lung Cancer ACCP Evidenced-Based Clinical Practice Guidelines (2nd Edition). CHEST Journal 2007, 132: 178s-201s. PMID: 17873168, DOI: 10.1378/chest.07-1360.Peer-Reviewed Original ResearchConceptsChest CT scanningPET scanningCT scanningMediastinal metastasesMetastatic diseaseStaging studiesLung cancerPractice guidelinesLung Cancer ACCP Evidence-Based Clinical Practice GuidelinesACCP Evidence-Based Clinical Practice GuidelinesEvidence-based clinical practice guidelinesMediastinal lymph node metastasisPositron emission tomography scanningTest characteristicsLung cancer guidelinesDistant metastatic diseaseLymph node metastasisClinical practice guidelinesMalignant lymph nodesNoninvasive imaging studiesAbnormal findingsCancer guidelinesLymph nodesNode metastasisAccurate staging
2004
Seeking a Home for a PET, Part 2 Defining the Appropriate Place for Positron Emission Tomography Imaging in the Staging of Patients With Suspected Lung Cancer
Detterbeck FC, Falen S, Rivera MP, Halle JS, Socinski MA. Seeking a Home for a PET, Part 2 Defining the Appropriate Place for Positron Emission Tomography Imaging in the Staging of Patients With Suspected Lung Cancer. CHEST Journal 2004, 125: 2300-2308. PMID: 15189955, DOI: 10.1378/chest.125.6.2300.Peer-Reviewed Original ResearchConceptsPositron emission tomographyLung cancerPET imagingClinical evaluationPET uptakeClinical stage I lung cancerStage I lung cancerStage III lung cancerEmission tomographyI lung cancerStrong clinical signsPositive PET resultsStaging of patientsInvasive mediastinal stagingNegative clinical evaluationExtrathoracic stagingMetastatic diseaseMediastinal stagingPrimary lesionClinical signsPET resultsPatientsCancerStagingDefinite role
2003
Invasive Staging of Non-small Cell Lung Cancer* A Review of the Current Evidence
Toloza EM, Harpole L, Detterbeck F, McCrory DC. Invasive Staging of Non-small Cell Lung Cancer* A Review of the Current Evidence. CHEST Journal 2003, 123: 157s-166s. PMID: 12527575, DOI: 10.1378/chest.123.1_suppl.157s.Peer-Reviewed Original ResearchConceptsEndoscopic ultrasound-guided needle aspirationNon-small cell lung cancerTransbronchial needle aspirationTransthoracic needle aspirationCell lung cancerNegative predictive valueStandard cervical mediastinoscopyLung cancerCervical mediastinoscopyNeedle aspirationComorbid illnessesPooled sensitivitySmall cell lung cancerPooled specificityUltrasound-guided needle aspirationCochrane Library databasesTest performance characteristicsDegree of suspicionInvasive stagingAnterior mediastinotomyMetastatic diseaseClinical stagingHistologic confirmationCurrent evidenceLibrary databasesSpecial Treatment Issues*
Detterbeck FC, Jones DR, Kernstine KH, Naunheim KS. Special Treatment Issues*. CHEST Journal 2003, 123: 244s-258s. PMID: 12527583, DOI: 10.1378/chest.123.1_suppl.244s.Peer-Reviewed Original ResearchConceptsMetachronous multiple primary lung cancerPrimary lung cancerSecond primary lung cancerLung cancerPancoast tumorPrimary tumorSame lobeNon-small cell lung cancerMultiple primary lung cancersLung cancer guidelinesMediastinal node involvementCell lung cancerNode involvementT4 tumorsMetachronous presentationMetastatic diseasePulmonary metastasesSolitary metastasisSurgical resectionCancer guidelinesSuch patientsBetter prognosisSatellite nodulesMultimodality approachAdrenal glandThe Noninvasive Staging of Non-small Cell Lung Cancer* The Guidelines
Silvestri GA, Tanoue LT, Margolis ML, Barker J, Detterbeck F. The Noninvasive Staging of Non-small Cell Lung Cancer* The Guidelines. CHEST Journal 2003, 123: 147s-156s. PMID: 12527574, DOI: 10.1378/chest.123.1_suppl.147s.Peer-Reviewed Original ResearchConceptsChest CT scanningMetastatic diseaseLung cancerCT scanningPhysical examinationClinical evaluationCT scanPET scansWhole body positron emission tomography scanningNon-small cell lung cancerImaging studiesPositron emission tomography scanningAbnormal scan findingsAbdominal CT scanCell lung cancerMalignant lymph nodesPresence of malignancyNoninvasive imaging studiesClinical evaluation toolCurative surgeryScan findingsBone scanLymph nodesTreatment optionsThorough history