2016
Detection of Occult Micrometastases in Patients With Clinical Stage I Non–Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance)
Martin LW, D'Cunha J, Wang X, Herzan D, Gu L, Abraham N, Demmy TL, Detterbeck FC, Groth SS, Harpole DH, Krasna MJ, Kernstine K, Kohman LJ, Patterson GA, Sugarbaker DJ, Vollmer RT, Maddaus MA, Kratzke RA. Detection of Occult Micrometastases in Patients With Clinical Stage I Non–Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance). Journal Of Clinical Oncology 2016, 34: 1484-1491. PMID: 26926677, PMCID: PMC4872306, DOI: 10.1200/jco.2015.63.4543.Peer-Reviewed Original ResearchConceptsN2 lymph nodesStage I NSCLCDisease-free survivalOccult micrometastasesLymph nodesCell lung cancerOverall survivalLung cancerStage IClinical stage I NSCLCPathologic stage I NSCLCComplete surgical stagingClinical stage IRT-PCRDecreased overall survivalNegative lymph nodesWorse survival rateSquamous cell carcinomaReal-time reverse transcriptase-polymerase chain reactionMulti-institutional trialReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionWarrants further investigationSurgical stagingPrognostic significance
2015
Evaluating the fate of patients who undergo resections of very large, node-negative lung cancers using the National Cancer DataBase
Liu J, Hancock JG, Moreno AC, Wang Z, Boffa DJ, Detterbeck FC, Kim AW. Evaluating the fate of patients who undergo resections of very large, node-negative lung cancers using the National Cancer DataBase. European Journal Of Cardio-Thoracic Surgery 2015, 49: 596-601. PMID: 25890936, DOI: 10.1093/ejcts/ezv139.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellChemoradiotherapy, AdjuvantDatabases, FactualFemaleFollow-Up StudiesHumansLung NeoplasmsLymph NodesMaleMiddle AgedNeoadjuvant TherapyNeoplasm StagingPneumonectomyRetrospective StudiesSurvival AnalysisTreatment OutcomeTumor BurdenUnited StatesConceptsPostoperative radiation therapyNational Cancer DatabaseNeoadjuvant chemoradiation therapyAdjuvant chemoradiation therapyChemoradiation therapyAdjuvant chemotherapyOverall survivalSurgical therapyLung cancerCancer DatabaseNode-negative lung cancerImproved OS relativeLymph node involvementKaplan-Meier methodCell lung cancerCox regression modelFate of patientsLog-rank testDifferent treatment modalitiesOS relativeNode involvementMetastatic diseaseSurgical resectionLymph nodesOS rates
2014
Learning Curve to Lymph Node Resection in Minimally Invasive Esophagectomy for Cancer
Dhamija A, Rosen JE, Dhamija A, Rothberg BE, Kim AW, Detterbeck FC, Boffa DJ. Learning Curve to Lymph Node Resection in Minimally Invasive Esophagectomy for Cancer. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 286-291. PMID: 25084251, DOI: 10.1097/imi.0000000000000082.Peer-Reviewed Original ResearchConceptsLymph node yieldComplete resectionInvasive esophagectomyNode yieldSurgeon experienceMinimally Invasive EsophagectomyLymph node resectionSingle-surgeon seriesHigh-grade dysplasiaNode resectionComplete lymphadenectomyLymph nodesRetrospective reviewSurgical marginsOncologic efficacyNegative marginsOncologic aspectsInstitutional databaseEsophageal cancerInvasive approachLate subgroupsOpen approachMultivariate analysisResectionSafe alternative
2012
Thoroughness of Mediastinal Staging in Stage IIIA Non-small Cell Lung Cancer
Vest MT, Tanoue L, Soulos PR, Kim AW, Detterbeck F, Morgensztern D, Gross CP. Thoroughness of Mediastinal Staging in Stage IIIA Non-small Cell Lung Cancer. Journal Of Thoracic Oncology 2012, 7: 188-195. PMID: 22134069, PMCID: PMC3253367, DOI: 10.1097/jto.0b013e318236ecbb.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiopsy, NeedleCarcinoma, Non-Small-Cell LungCohort StudiesComorbidityConfidence IntervalsGuideline AdherenceHumansLung NeoplasmsLymph NodesMediastinoscopyMediastinumMedicareMultivariate AnalysisNeoplasm StagingOdds RatioPositron-Emission TomographySEER ProgramSurvival AnalysisUnited StatesConceptsStage IIIA non-small cell lung cancerIIIA non-small cell lung cancerNon-small cell lung cancerInvasive stagingCell lung cancerMediastinal stagingLung cancerClinical stage IIIA non-small cell lung cancerEnd Results-Medicare databaseStage IIIA NSCLC patientsPositron emission tomography scanningPathologic lymph nodesIIIA NSCLC patientsMultivariable logistic regressionInvasive mediastinal stagingNSCLC patientsOlder patientsPatient characteristicsLymph nodesPatient factorsHistologic confirmationPractice patternsMedicare claimsMedicare beneficiariesPET scanning
2008
What to do with “Surprise” N2?: Intraoperative Management of Patients with Non-small Cell Lung Cancer
Detterbeck F. What to do with “Surprise” N2?: Intraoperative Management of Patients with Non-small Cell Lung Cancer. Journal Of Thoracic Oncology 2008, 3: 289-302. PMID: 18317073, DOI: 10.1097/jto.0b013e3181630ebd.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerMediastinal lymph node dissectionLymph node dissectionMediastinal lymph nodesPositive prognostic factorCell lung cancerAdjuvant therapyNode dissectionLung resectionLymph nodesMalignant involvementPrognostic factorsIntraoperative managementLung cancerPatientsConflicting dataResectionTherapyCancerDiseaseDissectionComprehensive review
2007
Beliefs among Physicians in the Diagnostic and Therapeutic Approach to Non-small Cell Lung Cancer
Stinchcombe TE, Detterbeck FC, Lin L, Rivera MP, Socinski MA. Beliefs among Physicians in the Diagnostic and Therapeutic Approach to Non-small Cell Lung Cancer. Journal Of Thoracic Oncology 2007, 2: 819-826. PMID: 17805059, DOI: 10.1097/jto.0b013e31811f478a.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Non-Small-Cell LungClinical CompetenceCombined Modality TherapyFemaleHumansLung NeoplasmsMaleNeoplasm StagingOutcome Assessment, Health CarePractice Guidelines as TopicQuality of LifeRetrospective StudiesSeverity of Illness IndexSurveys and QuestionnairesSurvival RateUnited StatesConceptsEvidence-based guidelinesStage IV diseaseSolitary pulmonary nodulesLung cancerPhysicians' beliefsPractice beliefsPulmonary nodulesNon-small cell lung cancerRole of chemotherapyStage III diseaseMediastinal lymph nodesPostoperative radiation therapyCell lung cancerTreatment of patientsMajority of physiciansQuality of lifePositron emission tomographyReminder e-mailsAdjuvant chemotherapyOperable patientsSurvival benefitChest PhysiciansLymph nodesPractice patternsRadiation therapyNoninvasive Staging of Non-small Cell Lung Cancer ACCP Evidenced-Based Clinical Practice Guidelines (2nd Edition)
Silvestri GA, Gould MK, Margolis ML, Tanoue LT, McCrory D, Toloza E, Detterbeck F. Noninvasive Staging of Non-small Cell Lung Cancer ACCP Evidenced-Based Clinical Practice Guidelines (2nd Edition). CHEST Journal 2007, 132: 178s-201s. PMID: 17873168, DOI: 10.1378/chest.07-1360.Peer-Reviewed Original ResearchConceptsChest CT scanningPET scanningCT scanningMediastinal metastasesMetastatic diseaseStaging studiesLung cancerPractice guidelinesLung Cancer ACCP Evidence-Based Clinical Practice GuidelinesACCP Evidence-Based Clinical Practice GuidelinesEvidence-based clinical practice guidelinesMediastinal lymph node metastasisPositron emission tomography scanningTest characteristicsLung cancer guidelinesDistant metastatic diseaseLymph node metastasisClinical practice guidelinesMalignant lymph nodesNoninvasive imaging studiesAbnormal findingsCancer guidelinesLymph nodesNode metastasisAccurate stagingInvasive Mediastinal Staging of Lung Cancer ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition)
Detterbeck FC, Jantz MA, Wallace M, Vansteenkiste J, Silvestri GA. Invasive Mediastinal Staging of Lung Cancer ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition). CHEST Journal 2007, 132: 202s-220s. PMID: 17873169, DOI: 10.1378/chest.07-1362.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerLymph nodesInvasive stagingMediastinal nodesClinical stage I non-small cell lung cancerLung Cancer ACCP Evidence-Based Clinical Practice GuidelinesACCP Evidence-Based Clinical Practice GuidelinesStage I non-small cell lung cancerNeedle techniqueEvidence-based clinical practice guidelinesLeft upper lobe tumorsNormal-sized lymph nodesPositron emission tomography scanningPET scan findingsUpper lobe tumorsMediastinal lymph nodesCell lung cancerClinical practice guidelinesStaging of patientsInvasive mediastinal stagingHigher FN rateInvasive confirmationMediastinal infiltrationNode enlargementScan findings
2006
Postoperative Radiotherapy for Stage II or III Non–Small-Cell Lung Cancer Using the Surveillance, Epidemiology, and End Results Database
Lally BE, Zelterman D, Colasanto JM, Haffty BG, Detterbeck FC, Wilson LD. Postoperative Radiotherapy for Stage II or III Non–Small-Cell Lung Cancer Using the Surveillance, Epidemiology, and End Results Database. Journal Of Clinical Oncology 2006, 24: 2998-3006. PMID: 16769986, DOI: 10.1200/jco.2005.04.6110.Peer-Reviewed Original ResearchConceptsT3-4 tumour stageUse of PORTN2 nodal diseaseEnd Results (SEER) databasePostoperative radiotherapyCell lung cancerLymph nodesNodal diseaseResults databaseTumor stageLung cancerNode stageStage IIHigher American Joint CommitteeAdvanced node stageAmerican Joint CommitteePopulation-based cohortLarger tumor sizeMedian followPerioperative mortalityMale sexTumor sizeSubset analysisCancer stageInclusion criteria
2003
Invasive Staging* The Guidelines
Detterbeck FC, DeCamp MM, Kohman LJ, Silvestri GA. Invasive Staging* The Guidelines. CHEST Journal 2003, 123: 167s-175s. PMID: 12527576, DOI: 10.1378/chest.123.1_suppl.167s.Peer-Reviewed Original ResearchConceptsInvasive staging proceduresTransbronchial needle aspirationTransthoracic needle aspirationStaging procedureNeedle aspirationInvasive staging testsMediastinal lymph nodesFine-needle aspirationInvasive stagingLow morbidityLymph nodesMalignant involvementMediastinal nodesRadiographic stagingLung cancerStaging testsEndoscopic ultrasoundMultidisciplinary discussionPhysiologic considerationsFalse negative rateMediastinoscopyParticular riskLow false negative rateReasonable alternativeThe Noninvasive Staging of Non-small Cell Lung Cancer* The Guidelines
Silvestri GA, Tanoue LT, Margolis ML, Barker J, Detterbeck F. The Noninvasive Staging of Non-small Cell Lung Cancer* The Guidelines. CHEST Journal 2003, 123: 147s-156s. PMID: 12527574, DOI: 10.1378/chest.123.1_suppl.147s.Peer-Reviewed Original ResearchConceptsChest CT scanningMetastatic diseaseLung cancerCT scanningPhysical examinationClinical evaluationCT scanPET scansWhole body positron emission tomography scanningNon-small cell lung cancerImaging studiesPositron emission tomography scanningAbnormal scan findingsAbdominal CT scanCell lung cancerMalignant lymph nodesPresence of malignancyNoninvasive imaging studiesClinical evaluation toolCurative surgeryScan findingsBone scanLymph nodesTreatment optionsThorough history