Cdc42 Deficiency Causes Ciliary Abnormalities and Cystic Kidneys
Choi SY, Chacon-Heszele MF, Huang L, McKenna S, Wilson FP, Zuo X, Lipschutz JH. Cdc42 Deficiency Causes Ciliary Abnormalities and Cystic Kidneys. Journal Of The American Society Of Nephrology 2013, 24: 1435-1450. PMID: 23766535, PMCID: PMC3752951, DOI: 10.1681/asn.2012121236.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCdc42 GTP-Binding ProteinCell ProliferationCiliaDisease Models, AnimalFibrosisIn Vitro TechniquesKidney Diseases, CysticKidney Tubules, CollectingKidney Tubules, DistalMiceMice, KnockoutMice, TransgenicMitogen-Activated Protein Kinase KinasesPhenotypeSignal TransductionVesicular Transport ProteinsZebrafishZebrafish ProteinsConceptsCiliary proteinsSynergistic genetic interactionMitogen-activated protein kinase activationSmall GTPase Cdc42Role of Cdc42Protein kinase activationKnockdown of Cdc42Trafficking complexGTPase Cdc42Genetic interactionsSec10 knockdownPolycystic kidney diseaseCyst cellsCdc42 knockdownPrimary ciliaPhotoreceptor ciliaCdc42Kinase activationExocystMAPK activationCiliogenesisSec10Same pathwayPathways resultsCdc42 deficiency