Genome-wide Association Study for AKI
Bhatraju P, Stanaway I, Palmer M, Menon R, Schaub J, Menez S, Srivastava A, Wilson F, Kiryluk K, Palevsky P, Naik A, Sakr S, Jarvik G, Parikh C, Ware L, Ikizler T, Siew E, Chinchilli V, Coca S, Garg A, Go A, Kaufman J, Kimmel P, Himmelfarb J, Wurfel M. Genome-wide Association Study for AKI. Kidney360 2023, 4: 870-880. PMID: 37273234, PMCID: PMC10371295, DOI: 10.34067/kid.0000000000000175.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGene locusAssociation studiesSingle-cell RNA sequencing dataHealthy living donorsLoop of HenleThick ascending limbWide significant associationsGenetic variantsGenome-wide significanceRNA sequencing dataKidney biopsyCommon genetic riskLiving donorsSubsequent sequelaeSerial evaluationFunctional annotationIntergenic regionAscending limbGene expressionSequencing dataRisk of AKIKidney biopsy tissueProximal tubular epithelial cellsMember 1 gene