Optimizing the Design and Analysis of Future AKI Trials
Legrand M, Bagshaw SM, Koyner JL, Schulman IH, Mathis MR, Bernholz J, Coca S, Gallagher M, Gaudry S, Liu KD, Mehta RL, Pirracchio R, Ryan A, Steubl D, Stockbridge N, Erlandsson F, Turan A, Wilson FP, Zarbock A, Bokoch MP, Casey JD, Rossignol P, Harhay MO. Optimizing the Design and Analysis of Future AKI Trials. Journal Of The American Society Of Nephrology 2022, 33: 1459-1470. PMID: 35831022, PMCID: PMC9342638, DOI: 10.1681/asn.2021121605.Peer-Reviewed Original ResearchConceptsAKI trialsClinical trialsTrial participantsTrial designAKI clinical trialsPerioperative patient populationsComplex clinical syndromeRisk of morbidityPragmatic trial designTreatment effectsClinical trial planningImportant treatment effectsClinical trial analysisAKI preventionClinical courseClinical syndromePatient populationTrial interventionClinical questionsClinical trialistsAKITrial infrastructureTrial planningTrialsEfficient enrollment