ALTERED BIOLOGICAL ACTIVITY ASSOCIATED WITH C-TERMINAL MODIFICATIONS OF IL-7
Görgün G, van der Spek J, Cosenza L, Menevse A, Foss F. ALTERED BIOLOGICAL ACTIVITY ASSOCIATED WITH C-TERMINAL MODIFICATIONS OF IL-7. Cytokine 2002, 20: 17-22. PMID: 12441142, DOI: 10.1006/cyto.2002.1974.Peer-Reviewed Original ResearchConceptsLigand-binding inducesSrc-related kinasesLigand-receptor interactionsAltered biological activityTyrosine phosphorylationC-terminal modificationBiological activityB leukemia cellsJAK3 kinaseHydrophobic residuesGamma subunitsSelective biological activityCarboxyterminal regionAliphatic amino acidsIL-7Amino acidsKinaseIL-7 receptorBinding antagonistsSubunitsIL-7R.Epithelial tissuesGammac subunitsCell functionIL-7RMechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells
Urbano A, Gorgun G, Foss F. Mechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells. Biochemical Pharmacology 2002, 63: 689-692. PMID: 11992636, DOI: 10.1016/s0006-2952(01)00916-9.Peer-Reviewed Original ResearchConceptsCytochrome c/ApafPhosphatidylinositol-3-kinase/AktHematopoietic cellsTyrphostin tyrosine kinase inhibitorKinase/AktChronic myelogenous leukemia blastsMechanism of apoptosisCell line NALM-6BAD complexLeukemia cellsPhosphorylation stateC-CblAdaptor moleculeGrowth arrestAltered phosphorylationChronic myelogenous leukemia cellsMyelogenous leukemia cellsProgenitor cellsApoptosisTyrphostin AG957AG957NALM-6Kinase inhibitorsGrowth inhibitionAkt