Hodgkin’s Lymphoma Cell Lines Have up-Regulated IL-3 Receptor α (IL-3Rα) Expression and Are Sensitive to SL-401, An IL-3Rα Targeted Drug,
Diefenbach C, Sabado R, Brooks C, Baquero-Buitrago J, Cruz C, Vengco I, Montanari F, Marchi E, Scotto L, Cirrito T, Bergstein I, O'Connor O. Hodgkin’s Lymphoma Cell Lines Have up-Regulated IL-3 Receptor α (IL-3Rα) Expression and Are Sensitive to SL-401, An IL-3Rα Targeted Drug,. Blood 2011, 118: 3737. DOI: 10.1182/blood.v118.21.3737.3737.Peer-Reviewed Original ResearchHodgkin Reed-Sternberg cellsSL-401CD123 expressionHodgkin's lymphomaComplete responseTreatment strategiesLymphoma cell linesMyeloid leukemiaCell linesAutologous stem cell transplantMalignant Hodgkin Reed-Sternberg (HRS) cellsCell viabilityPrimary refractory diseaseRefractory Hodgkin lymphomaSecond-line chemotherapySecond-line therapyHigh expressionEffective therapeutic optionStem cell transplantReceptor α expressionAcute myeloid leukemiaChronic myeloid leukemiaClassical Hodgkin lymphomaPotential treatment strategyNovel treatment strategies