2023
Longitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease
Mandino F, Shen X, Desrosiers-Gregoire G, O'Connor D, Mukherjee B, DeLuca K, Hamodi A, Owens A, Ha Y, Qu A, Onofrey J, Papademetris X, Chakravarty M, Crair M, Strittmatter S, Lake E. Longitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/3914.Peer-Reviewed Original ResearchMouse model of Alzheimer's diseaseModel of Alzheimer's diseaseMesoscale calcium imagingAlzheimer's diseaseBehavioral deficitsExcitatory neural activityMultimodal neuroimagingBOLD signalSimultaneous fMRINeuroimaging changesNeural activityBOLD fMRIPreliminary evidenceCalcium imagingClinically accessible biomarkersMesoscopic calcium imagingSpontaneous activityFMRINeuroimagingBOLDDeficitsComplex relationship
2021
Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics
Salvan P, Lazari A, Vidaurre D, Mandino F, Johansen-Berg H, Grandjean J. Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics. Cell Reports 2021, 37: 109954. PMID: 34731612, PMCID: PMC8609366, DOI: 10.1016/j.celrep.2021.109954.Peer-Reviewed Original ResearchConceptsBrain-wide dynamicsFrequency-dependent fashionEntorhinal cortex dysfunctionHuman neuroimaging studiesBasic neuronal mechanismsEntorhinal cortex activityExcitatory neuronsTransgenic modelStimulation frequencyCortex activityFMRI fluctuationsNeuronal mechanismsAnatomical circuitsNeuroimaging studiesNeural activityNeuronal spikingCognitive diseasesFMRI analysisDysfunctionModulationDiseaseMiceNeuronsActivityBrain