Lipocalin‐Type Prostaglandin d Synthase Conjugates as Magnetic Resonance Imaging Contrast Agents for Detecting Amyloid β‐Rich Regions in the Brain of Live Alzheimer's Disease Mice
Sharma B, Grandjean J, Phillips M, Kumar A, Mandino F, Yeow L, Low K, Nandwana V, Dravid V, Bengang X, Lim S, Pervushin K. Lipocalin‐Type Prostaglandin d Synthase Conjugates as Magnetic Resonance Imaging Contrast Agents for Detecting Amyloid β‐Rich Regions in the Brain of Live Alzheimer's Disease Mice. Advanced NanoBiomed Research 2021, 1 DOI: 10.1002/anbr.202100019.Peer-Reviewed Original ResearchMagnetic resonance imagingAlzheimer's diseaseDisease miceNon-invasive intranasal administrationEarly detectionAlzheimer's disease micePotential neuroprotective functionQuality of lifeContrast-enhanced visualizationLipocalin-type prostaglandin D synthaseBrain amyloidIntranasal administrationNeuroprotective functionDetection of amyloidProstaglandin D synthaseCerebrospinal fluidAmyloid β-peptideL-PGDSCurrent diagnosisMouse brainResonance imagingBrain regionsLow success rateNeuronal cellsSuccess rate