2009
Fgfr1 Is Required for Cortical Regeneration and Repair after Perinatal Hypoxia
Fagel DM, Ganat Y, Cheng E, Silbereis J, Ohkubo Y, Ment LR, Vaccarino FM. Fgfr1 Is Required for Cortical Regeneration and Repair after Perinatal Hypoxia. Journal Of Neuroscience 2009, 29: 1202-1211. PMID: 19176828, PMCID: PMC2768410, DOI: 10.1523/jneurosci.4516-08.2009.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnimalsAnimals, NewbornBromodeoxyuridineCell ProliferationCerebral CortexCreatinineDNA-Binding ProteinsGlial Fibrillary Acidic ProteinHypoxiaMiceMice, Inbred C57BLMice, TransgenicNerve RegenerationNeurogenesisNeuronsOlfactory BulbParvalbuminsPhosphopyruvate HydrataseReceptor, Fibroblast Growth Factor, Type 1T-Box Domain ProteinsConceptsWild-type miceCortical neuronsOlfactory bulbSubventricular zoneChronic postnatal hypoxiaNeonatal hypoxic injuryPersistent behavioral deficitsExcitatory cortical neuronsSVZ cell proliferationCell proliferationPostnatal day 3Receptor 1 geneNormoxic miceOB neurogenesisReactive neurogenesisPerinatal hypoxiaPostnatal hypoxiaNeuronal recoveryFibroblast growth factor receptor 1 (FGFR1) geneHypoxic miceChronic hypoxiaGABAergic interneuronsHypoxic injuryResidual deficitsCortical regeneration
2006
Midline radial glia translocation and corpus callosum formation require FGF signaling
Smith KM, Ohkubo Y, Maragnoli ME, Rašin M, Schwartz ML, Šestan N, Vaccarino FM. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nature Neuroscience 2006, 9: 787-797. PMID: 16715082, DOI: 10.1038/nn1705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell MovementCell ShapeCerebral CortexCorpus CallosumDown-RegulationFemaleFibroblast Growth Factor 8Fibroblast Growth FactorsGrowth ConesMaleMiceMice, KnockoutMice, TransgenicNeurogliaReceptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2RNA InterferenceSignal TransductionConceptsRadial glial cellsGlial cellsSomal translocationRadial gliaCorpus callosum formationReceptor 1 geneCallosal dysgenesisCerebral cortexFibroblast growth factor receptor 1 (FGFR1) geneIndusium griseumDorsomedial cortexDorsolateral cortexKnockout miceCortexAstrogliaApical endfeetFGFR1 geneAstrocytesGliaAxon guidanceDorsal midlinePrecise targetingCellsUnexpected roleFGF