2004
Chronic neonatal hypoxia leads to long term decreases in the volume and cell number of the rat cerebral cortex
Schwartz ML, Vaccarino F, Chacon M, Yan WL, Ment LR, Stewart WB. Chronic neonatal hypoxia leads to long term decreases in the volume and cell number of the rat cerebral cortex. Seminars In Perinatology 2004, 28: 379-388. PMID: 15693394, DOI: 10.1053/j.semperi.2004.10.009.Peer-Reviewed Original ResearchConceptsDays of hypoxiaPreterm birth resultsNeuronal sizeBirth resultsHypoxic exposureCell numberChronic neonatal hypoxiaChronic sublethal hypoxiaNeonatal rodent modelPerinatal period altersRat cerebral cortexNeuronal cell numberBcl-2Glial cell numbersNormoxic environmentPostnatal day 3Cortical cell numberSignificant neurodevelopmental disabilitiesWestern blot analysisPreterm birthNeonatal hypoxiaNormoxic exposureCerebral cortexChronic hypoxiaControl pups
1994
Excitatory amino acid receptors in glial progenitor cells: Molecular and functional properties
Gallo V, Patneau D, Mayer M, Vaccarino F. Excitatory amino acid receptors in glial progenitor cells: Molecular and functional properties. Glia 1994, 11: 94-101. PMID: 7927651, DOI: 10.1002/glia.440110204.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsCells, CulturedCerebral CortexDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGenes, Immediate-EarlyGlutamic AcidImmediate-Early ProteinsKainic AcidMembrane PotentialsN-MethylaspartateNerve Tissue ProteinsNeurotoxinsOligodendrogliaRatsReceptors, GlutamateStem CellsTranscription FactorsConceptsCG-4 cellsAMPA receptor antagonist CNQXWhole-cell patch-clamp recordingsExcitatory amino acid receptorsProgenitor cellsAmino acid receptorsRat cerebral cortexPatch-clamp recordingsGlial progenitor cellsGlutamate receptor subunitsAgonists L-glutamateGlutamate-gated channelsImmediate early gene NGFIAntagonist CNQXCerebral cortexGABA antibodyPrimary cell linesGlutamate receptorsTransient elevationAcid receptorsReceptor subunitsOligodendrocyte lineageOligodendrocyte progenitorsL-glutamateKainate
1993
Induction of immediate early genes by cyclic AMP in primary cultures of neurons from rat cerebral cortex
Vaccarino FM, Hayward MD, Le HN, Hartigan DJ, Duman RS, Nestler EJ. Induction of immediate early genes by cyclic AMP in primary cultures of neurons from rat cerebral cortex. Brain Research 1993, 19: 76-82. PMID: 8103187, DOI: 10.1016/0169-328x(93)90151-e.Peer-Reviewed Original ResearchMeSH Keywords2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAnimalsAnimals, NewbornBucladesineCells, CulturedCerebral CortexColforsinCyclic AMPDNA-Binding ProteinsDopamine AgentsEarly Growth Response Protein 1ErgolinesGene Expression RegulationGenes, fosGenes, junGlutamatesGlutamic AcidImmediate-Early ProteinsImmunohistochemistryKineticsNeurogliaNeuronsQuinpiroleRatsRNA, MessengerSecond Messenger SystemsTranscription FactorsVasoactive Intestinal PeptideConceptsVasoactive intestinal peptideRat cerebral cortexCerebral cortexExcitatory amino acid receptor antagonistsDibutyryl cAMPAmino acid receptor antagonistsPrimary culturesC-fosDihydropyridine-sensitive calcium channelsAcid receptor antagonistsIEG inductionCalcium-free mediumCAMP second messenger pathwayIEGs c-fosSKF 38393Immediate-early gene transcription factorsIntestinal peptideReceptor antagonistReceptor agonistSecond messenger pathwaysCalcium channelsDifferentiated neuronsBrief stimulationImmediate early genesIEG expression
1991
Modulation of Protein Kinase C Translocation by Excitatory and Inhibitory Amino Acids in Primary Cultures of Neurons
Vaccarino F, Liljequist S, Tallman J. Modulation of Protein Kinase C Translocation by Excitatory and Inhibitory Amino Acids in Primary Cultures of Neurons. Journal Of Neurochemistry 1991, 57: 391-396. PMID: 1649249, DOI: 10.1111/j.1471-4159.1991.tb03765.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsAnimals, NewbornBicucullineCell MembraneCells, CulturedCerebral CortexCorpus StriatumDizocilpine MaleateGlutamatesKineticsNeuronsOxadiazolesPhorbol 12,13-DibutyrateProtein Kinase CRatsRats, Inbred StrainsReceptors, AMPAReceptors, N-Methyl-D-AspartateReceptors, NeurotransmitterTetrodotoxinConceptsProtein kinase CPKC translocationAmino acidsExtracellular mediumProtein kinase C translocationAmino acid stimulationPrimary culturesKinase CC translocationExcitatory amino acid receptorsTranslocationExcitatory amino acid stimulationImine hydrogen maleateExcitatory amino acidsAmino acid receptorsRat cerebral cortexInhibitory amino acidsNMDA receptor antagonistAbsence of calciumAcid receptorsPhysiological concentrationsCerebral cortexMetabotropic receptorsReceptor antagonistAMPA receptors