1987
Subcellular Location and Neuronal Release of Diazepam Binding Inhibitor
Ferrarese C, Vaccarino F, Alho H, Mellstrom B, Costa E, Guidotti A. Subcellular Location and Neuronal Release of Diazepam Binding Inhibitor. Journal Of Neurochemistry 1987, 48: 1093-1102. PMID: 3819722, DOI: 10.1111/j.1471-4159.1987.tb05632.x.Peer-Reviewed Original ResearchConceptsDBI-like immunoreactivitySlices of hypothalamusCerebral cortical neuronsGamma-aminobutyric acid receptorsRat brain neuronsDiazepam binding inhibitorAllosteric modulatory sitesVeratridine depolarizationNeuronal releaseCerebral cortexMicroM tetrodotoxinSlices of liverPeripheral organsCNS neuronsCortical neuronsBinding of benzodiazepinesCortical astrocytesBrain neuronsNeuromodulatory substancesRat brainSynaptosomal lysatesModulatory siteMet5-enkephalinAcid receptorsNeurons
1986
Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures.
Vicini S, Alho H, Costa E, Mienville JM, Santi MR, Vaccarino FM. Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 9269-9273. PMID: 3097650, PMCID: PMC387117, DOI: 10.1073/pnas.83.23.9269.Peer-Reviewed Original ResearchConceptsInhibitory synaptic currentsSynaptic currentsRo 15Whole-cell patch-clamp techniqueActions of flunitrazepamGamma-aminobutyric acid receptorsNeonatal rat cortexCortical cell culturesPatch-clamp techniqueImidazobenzodiazepine Ro 15High-affinity ligandsRat cortexSynaptic transmissionPostsynaptic cellElectrical stimulationEndogenous ligandAcid receptorsImmunocytochemical stainingPrimary culturesNeuronsFlunitrazepamCell culturesIntrinsic activityDerivative methylAllosteric regulatory site