2019
Statin Short-term Inhibition of Insulin Sensitivity and Secretion During Acute Phase of ST-Elevation Myocardial Infarction
Sposito A, Carvalho L, Moura F, Campos-Staffico A, Cintra R, Nadruz W, Almeida O, Quinaglia e Silva J. Statin Short-term Inhibition of Insulin Sensitivity and Secretion During Acute Phase of ST-Elevation Myocardial Infarction. Scientific Reports 2019, 9: 16401. PMID: 31704948, PMCID: PMC6841947, DOI: 10.1038/s41598-019-52111-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultDrug Administration ScheduleFemaleHospitalizationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInsulinInsulin ResistanceMaleMiddle AgedProspective StudiesSimvastatinST Elevation Myocardial InfarctionYoung AdultConceptsEuglycemic hyperinsulinemic clampMyocardial infarctionInsulin sensitivityAcute phaseShort-course treatmentInfluence glucose homeostasisAssociated with mortalityDose-dependent mannerStable patientsClinical outcomesProspective studyStatinsHyperinsulinemic clampPatientsExperimental modelGlucose homeostasisHOMA2DaysOmega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction
Campos-Staffico A, Costa A, Carvalho L, Moura F, Santos S, Coelho-Filho O, Nadruz W, Quinaglia e Silva J, Sposito A. Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction. Nutrition Journal 2019, 18: 29. PMID: 31060562, PMCID: PMC6503367, DOI: 10.1186/s12937-019-0455-1.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonance imagingAcute inflammatory responseCardiac remodelingInflammatory responseAssociated with attenuated inflammatory responsesLeft ventricle ejection fractionBrain-type natriuretic peptideHs-C-reactive proteinFood frequency questionnaireEnd-diastolic volumeReduced daily intakeLeft ventricular remodelingOmega-3 intakeLeft ventricle end-diastolic volumeOmega-3 polyunsaturated fatty acidsExcessive inflammatory responseAssociated with attenuationAnti-inflammatory effectsMagnetic resonance imagingFrequency questionnaireEjection fractionNatriuretic peptideResultsThe intakeInflammatory markersVentricular remodeling
2017
Adverse outcome has a U-shaped relation with acute phase change in insulin sensitivity after ST-Elevation Myocardial Infarction
Moura F, Cintra R, Carvalho L, Santos S, Modolo R, Munhoz D, Quinaglia e Silva J, Coelho O, Nadruz W, Sposito A. Adverse outcome has a U-shaped relation with acute phase change in insulin sensitivity after ST-Elevation Myocardial Infarction. International Journal Of Cardiology 2017, 254: 16-22. PMID: 29246426, DOI: 10.1016/j.ijcard.2017.11.111.Peer-Reviewed Original ResearchMeSH KeywordsAgedCohort StudiesFemaleFollow-Up StudiesHumansInsulinInsulin ResistanceMaleMiddle AgedProspective StudiesST Elevation Myocardial InfarctionTreatment OutcomeConceptsST-elevation MIGRACE risk scoreInsulin sensitivity changesIntra-hospital deathMyocardial infarctionFollow-upMI hospitalizationAssociated with increased mortalityMarkers of glucose metabolismCox regression modelsInsulin provision therapyProspective cohortRisk scoreNet reclassification indexCardiac eventsAdverse cardiac eventsUpstream markersCox regressionAdverse outcomesHomeostasis model assessmentEstimate insulin sensitivityReclassification indexU-shaped relationStress hyperglycemiaInsulin sensitivity