2022
Abstract 14830: Comparative Cost-Effectiveness of Cardioprotective Glucose-Lowering Therapies for Type 2 Diabetes in a Middle-Income Country: A Bayesian Network Model
Carvalho L, Nogueira A, Antunes J, Moura F, Luchiari B, Bonilha I, Nadruz W, Gaziano M, Gaziano T, Sposito A. Abstract 14830: Comparative Cost-Effectiveness of Cardioprotective Glucose-Lowering Therapies for Type 2 Diabetes in a Middle-Income Country: A Bayesian Network Model. Circulation 2022, 146: a14830-a14830. DOI: 10.1161/circ.146.suppl_1.14830.Peer-Reviewed Original ResearchIncremental cost-effectiveness ratioGLP-1RAMiddle-income countriesType 2 diabetesCardiovascular eventsRisk of non-fatal cardiovascular eventsFollow-up >Pre-specified endpointsCohort of T2D patientsNon-fatal cardiovascular eventsGlucose-lowering therapySecondary prevention cohortAdverse cardiovascular eventsAnti-diabetic therapyRandomized clinical trialsCost-effectiveness ratioBrazilian public health systemDouble-blindGLP1-RAPublic health systemPrevention cohortProspective cohortT2D subjectsHeart failureT2D patients
2017
Adverse outcome has a U-shaped relation with acute phase change in insulin sensitivity after ST-Elevation Myocardial Infarction
Moura F, Cintra R, Carvalho L, Santos S, Modolo R, Munhoz D, Quinaglia e Silva J, Coelho O, Nadruz W, Sposito A. Adverse outcome has a U-shaped relation with acute phase change in insulin sensitivity after ST-Elevation Myocardial Infarction. International Journal Of Cardiology 2017, 254: 16-22. PMID: 29246426, DOI: 10.1016/j.ijcard.2017.11.111.Peer-Reviewed Original ResearchConceptsST-elevation MIGRACE risk scoreInsulin sensitivity changesIntra-hospital deathMyocardial infarctionFollow-upMI hospitalizationAssociated with increased mortalityMarkers of glucose metabolismCox regression modelsInsulin provision therapyProspective cohortRisk scoreNet reclassification indexCardiac eventsAdverse cardiac eventsUpstream markersCox regressionAdverse outcomesHomeostasis model assessmentEstimate insulin sensitivityReclassification indexU-shaped relationStress hyperglycemiaInsulin sensitivity