2021
Defective Allele of the Neuronal Nitric Oxide Synthase Gene Increases Insulin Resistance During Acute Phase of Myocardial Infarction
Nóbrega O, Campos-Staffico A, Oliveira E, Munhoz D, Moura F, Carvalho L, Soares A, Gomes C, Tonet-Furioso A, Sposito A, . Defective Allele of the Neuronal Nitric Oxide Synthase Gene Increases Insulin Resistance During Acute Phase of Myocardial Infarction. International Journal Of General Medicine 2021, 14: 3669-3676. PMID: 34321912, PMCID: PMC8312503, DOI: 10.2147/ijgm.s313661.Peer-Reviewed Original ResearchST-elevation myocardial infarctionFlow-mediated dilationNeuronal nitric oxide synthaseAcute phaseInsulin-resistant statesDefective allelesAssociated with poorer endothelial functionInsulin resistanceMyocardial infarctionAssociated with insulin-resistant statesInsulin sensitivityCirculating NO poolB cell functionAcute phase of myocardial infarctionNitric oxidePlasma NO levelsPredictors of mortalityPhase of myocardial infarctionPoorer endothelial functionBlood glucose balanceInfluence insulin responsivenessNitric oxide synthaseConsecutive patientsAA patientsGlycemic disorders
2019
Statin Short-term Inhibition of Insulin Sensitivity and Secretion During Acute Phase of ST-Elevation Myocardial Infarction
Sposito A, Carvalho L, Moura F, Campos-Staffico A, Cintra R, Nadruz W, Almeida O, Quinaglia e Silva J. Statin Short-term Inhibition of Insulin Sensitivity and Secretion During Acute Phase of ST-Elevation Myocardial Infarction. Scientific Reports 2019, 9: 16401. PMID: 31704948, PMCID: PMC6841947, DOI: 10.1038/s41598-019-52111-x.Peer-Reviewed Original ResearchConceptsEuglycemic hyperinsulinemic clampMyocardial infarctionInsulin sensitivityAcute phaseShort-course treatmentInfluence glucose homeostasisAssociated with mortalityDose-dependent mannerStable patientsClinical outcomesProspective studyStatinsHyperinsulinemic clampPatientsExperimental modelGlucose homeostasisHOMA2DaysReciprocal Multifaceted Interaction Between HDL (High-Density Lipoprotein) and Myocardial Infarction
Sposito A, de Lima-Junior J, Moura F, Barreto J, Bonilha I, Santana M, Virginio V, Sun L, Carvalho L, Soares A, Nadruz W, Feinstein S, Nofer J, Zanotti I, Kontush A, Remaley A. Reciprocal Multifaceted Interaction Between HDL (High-Density Lipoprotein) and Myocardial Infarction. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 1550-1564. PMID: 31189429, DOI: 10.1161/atvbaha.119.312880.Peer-Reviewed Original ResearchConceptsMyocardial infarctionHigh-density lipoproteinSphingosine-1-phosphateSpectrum of signaling pathwaysEndothelin-1Cardiac functionCardioprotective benefitsTherapeutic advancesClinical studiesIschemia/reperfusion injuryProinflammatory moleculesAnimal modelsInsulin sensitivityHDLInfarctionMitochondrial channelsFunctional changesOxidative stressSignaling pathway
2017
Adverse outcome has a U-shaped relation with acute phase change in insulin sensitivity after ST-Elevation Myocardial Infarction
Moura F, Cintra R, Carvalho L, Santos S, Modolo R, Munhoz D, Quinaglia e Silva J, Coelho O, Nadruz W, Sposito A. Adverse outcome has a U-shaped relation with acute phase change in insulin sensitivity after ST-Elevation Myocardial Infarction. International Journal Of Cardiology 2017, 254: 16-22. PMID: 29246426, DOI: 10.1016/j.ijcard.2017.11.111.Peer-Reviewed Original ResearchConceptsST-elevation MIGRACE risk scoreInsulin sensitivity changesIntra-hospital deathMyocardial infarctionFollow-upMI hospitalizationAssociated with increased mortalityMarkers of glucose metabolismCox regression modelsInsulin provision therapyProspective cohortRisk scoreNet reclassification indexCardiac eventsAdverse cardiac eventsUpstream markersCox regressionAdverse outcomesHomeostasis model assessmentEstimate insulin sensitivityReclassification indexU-shaped relationStress hyperglycemiaInsulin sensitivity
2013
Validation of surrogate indexes of insulin sensitivity in acute phase of myocardial infarction based on euglycemic-hyperinsulinemic clamp
Moura F, Carvalho L, Cintra R, Martins N, Figueiredo V, Quinaglia e Silva J, Almeida O, Coelho O, Sposito A. Validation of surrogate indexes of insulin sensitivity in acute phase of myocardial infarction based on euglycemic-hyperinsulinemic clamp. AJP Endocrinology And Metabolism 2013, 306: e399-e403. PMID: 24347056, DOI: 10.1152/ajpendo.00566.2013.Peer-Reviewed Original ResearchConceptsQuantitative insulin sensitivity check indexEuglycemic-hyperinsulinemic clampHomeostatic model assessmentHOMA-IRInsulin sensitivityMyocardial infarctionSurrogate indexHomeostatic model assessment of insulin resistanceModel assessment of insulin resistanceConsecutive nondiabetic patientsHomeostatic model assessment of insulin sensitivityAssessment of insulin resistanceST-segment elevation MISurrogate indexes of insulin sensitivityInsulin sensitivity check indexIndices of insulin sensitivityAcute phase of myocardial infarctionReceiver operating characteristic curveAcute MI patientsAssessment of insulin sensitivityPhase of myocardial infarctionGold standard reference methodBland-Altman plotsOperating characteristics curvePoor patient outcomesValidation of HOMA2S in acute phase of myocardial infarction, based on euglycemic-hyperinsulinemic clamp
Carvalho L, Moura F, Gomes N, Sposito A. Validation of HOMA2S in acute phase of myocardial infarction, based on euglycemic-hyperinsulinemic clamp. European Heart Journal 2013, 34: p1272. DOI: 10.1093/eurheartj/eht308.p1272.Peer-Reviewed Original ResearchAcute phase of MIEuglycemic-hyperinsulinemic clampPhase of MIMyocardial infarctionInsulin sensitivityAcute phaseST-segment elevation MIROC curveEvaluate blood glucose levelsArea under the curveAcute phase of myocardial infarctionHomeostasis model assessmentBland-Altman graphsPhase of myocardial infarctionBland-Altman analysisLinear regressionHyperinsulinemic-euglycemic clampHeart StudyGold standard methodBlood glucose levelsNondiabetic patientsStressful situationsCardiovascular eventsElevation MIEndothelial function
2012
High-density lipoprotein levels are strongly associated with the recovery rate of insulin sensitivity during the acute phase of myocardial infarction: A study by euglycemic hyperinsulinemic clamp
Carvalho L, Martins N, Moura F, Cintra R, Almeida O, Quinaglia e Silva J, Sposito A, Group B. High-density lipoprotein levels are strongly associated with the recovery rate of insulin sensitivity during the acute phase of myocardial infarction: A study by euglycemic hyperinsulinemic clamp. Journal Of Clinical Lipidology 2012, 7: 24-28. PMID: 23351579, DOI: 10.1016/j.jacl.2012.10.003.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAge FactorsAgedBlood Chemical AnalysisFemaleGlucose Clamp TechniqueHospitalizationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInsulin ResistanceLipoproteins, HDLMagnetic Resonance ImagingMaleMiddle AgedMyocardial InfarctionSeverity of Illness IndexSex FactorsTreatment OutcomeTriglyceridesConceptsAcute phase of MIHigh HDL groupHDL groupHDL-CPhase of MIMyocardial infarctionEuglycemic hyperinsulinemic clampAcute phaseInsulin sensitivityIS indexAssociated with increased morbidityConsecutive nondiabetic patientsHyperinsulinemic clampLevels of HDL-CPlasma levels of HDL-CST-segment elevation MIHigh-density lipoprotein levelsLow HDL groupHigh-density lipoprotein (HDLHDL-C levelsPlasma HDL-CWaist circumferenceRate of ISDecrease of insulin sensitivityLipoprotein (HDL
2011
Abstract 18367: High Density Lipoprotein Independently Modulates Insulin Sensitivity and Secretion During Acute Phase of Myocardial Infarction
Carvalho L, Cintra R, Araújo A, Moura F, Quináglia e Silva J, Coelho O, Sposito A. Abstract 18367: High Density Lipoprotein Independently Modulates Insulin Sensitivity and Secretion During Acute Phase of Myocardial Infarction. Circulation 2011, 124 DOI: 10.1161/circ.124.suppl_21.a18367.Peer-Reviewed Original ResearchHDL-C quartileHDL-CC-peptideMyocardial infarctionDisposition indexStress hyperglycemiaPlasma insulinInsulin sensitivityBlood glucoseConsecutive non-diabetic patientsAcute phaseHDL plasma levelsNon-diabetic patientsPlasma C-peptideAcute phase of MIAcute phase of myocardial infarctionHDL-C levelsST-elevation MIMultivariate analysis modelPhase of myocardial infarctionInfluence of HDLPhase of MIPlasma levelsTransient decreasePatientsHigh plasma HDL-C attenuates stress hyperglycemia during acute phase of myocardial infarction
Carvalho L, Cintra R, Moura F, Martins N, Quinaglia e Silva J, Coelho O, Sposito A, Group O. High plasma HDL-C attenuates stress hyperglycemia during acute phase of myocardial infarction. Atherosclerosis 2011, 220: 231-236. PMID: 22018645, DOI: 10.1016/j.atherosclerosis.2011.09.044.Peer-Reviewed Original ResearchConceptsHDL-C levelsHDL-C quartilePlasma HDL-C levelsHDL-CC-peptideMyocardial infarctionAcute phaseStress hyperglycemiaInsulin sensitivityAssociated with HDL-C levelsConsecutive non-diabetic patientsNon-diabetic patientsAcute phase of MILow plasma HDL-C levelsAcute phase of myocardial infarctionST-segment elevationPhase of myocardial infarctionBeta-cell functionAssess insulin sensitivityPhase of MIImproved insulin sensitivityBlood glucose changesPlasma glucoseQuartilePlasma insulin