P4626Neuronal nitric oxide sintetase polymorphism increases sympathetic activity and recurrent cardiovascular events after myocardial infarction
Oliveira E, Munhoz D, Carvalho L, Moura F, Machado-Silva W, Figueiredo V, Nobrega O, Sposito A. P4626Neuronal nitric oxide sintetase polymorphism increases sympathetic activity and recurrent cardiovascular events after myocardial infarction. European Heart Journal 2019, 40: ehz745.1008. DOI: 10.1093/eurheartj/ehz745.1008.Peer-Reviewed Original ResearchST-elevation myocardial infarctionMajor cardiovascular eventsT allele carriersFlow-mediated dilationRecurrent major cardiovascular eventsCardiovascular eventsSympathetic activityClinical impactT alleleAcute phase of ST-elevation myocardial infarctionAssociated with increased sympathetic toneDecreased FMDMyocardial infarctionClinical follow-upCox regression analysisIncreased sympathetic activityNitric oxideRecurrent cardiovascular eventsAutonomic nervous system modulationCardiac sudden deathElevation myocardial infarctionDecreased parasympathetic activityPeripheral nervous systemSimvastatin doseSympathetic tone