2021
Dapagliflozin effect on endothelial dysfunction in diabetic patients with atherosclerotic disease: a randomized active-controlled trial
Sposito A, Breder I, Soares A, Kimura-Medorima S, Munhoz D, Cintra R, Bonilha I, Oliveira D, Breder J, Cavalcante P, Moreira C, Moura F, de Lima-Junior J, do Carmo H, Barreto J, Nadruz W, Carvalho L, Quinaglia T. Dapagliflozin effect on endothelial dysfunction in diabetic patients with atherosclerotic disease: a randomized active-controlled trial. Cardiovascular Diabetology 2021, 20: 74. PMID: 33771149, PMCID: PMC8004411, DOI: 10.1186/s12933-021-01264-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBenzhydryl CompoundsBiomarkersBlood GlucoseBrazilCarotid Artery DiseasesDiabetes Mellitus, Type 2Drug Therapy, CombinationEndothelium, VascularFemaleGlucosidesGlyburideGlycated HemoglobinHumansMaleMetforminMiddle AgedProspective StudiesSodium-Glucose Transporter 2 InhibitorsTime FactorsTreatment OutcomeVasodilationConceptsFlow-mediated dilationSodium-glucose cotransporter-2 inhibitorsCoprimary endpointsAtherosclerotic diseaseWeeks of therapyResultsNinety-seven patientsMacrovascular endothelial functionCotransporter-2 inhibitorsType 2 diabetes mellitusRandomized active-controlled trialActive-controlled trialCarotid intima-media thicknessRandomized clinical trialsIntima-media thicknessDapagliflozin EffectGlibenclamide armsDapagliflozin groupArterial wall functionOpen-labelSGLT2i treatmentGlibenclamide groupResultsNinety-sevenSingle-centerMedian HbA1cCarotid atherosclerotic disease
2014
Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity
Virginio V, Nunes V, Moura F, Menezes F, Andreollo N, Rogerio F, Scherrer D, Quintão E, Nakandakare E, Petrucci O, Nadruz-Junior W, de Faria E, Sposito A. Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. Free Radical Research 2014, 49: 199-203. PMID: 25465091, DOI: 10.3109/10715762.2014.992894.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseSevere peripheral arterial diseaseAtherosclerotic diseasePlasma C-reactive proteinFree of atherosclerotic plaquesSystemic inflammatory activityC-reactive proteinPeripheral atherosclerotic diseaseFree radical-mediated mechanismAtherosclerotic plaquesAdvanced atherosclerotic diseaseArterial tissueArtery diseaseInflammatory activityPlasma concentrationsEnzymatic stressDiseaseArteryRadical-mediated mechanismPlasmaPlaqueOxysterolsTissue
2012
Atherosclerotic disease in octogenarians: A challenge for science and clinical practice
Freitas W, Carvalho L, Moura F, Sposito A. Atherosclerotic disease in octogenarians: A challenge for science and clinical practice. Atherosclerosis 2012, 225: 281-289. PMID: 22858284, DOI: 10.1016/j.atherosclerosis.2012.06.070.Peer-Reviewed Original Research