2023
Body Composition, Coronary Microvascular Dysfunction, and Future Risk of Cardiovascular Events Including Heart Failure
Souza A, Rosenthal M, Moura F, Divakaran S, Osborne M, Hainer J, Dorbala S, Blankstein R, Di Carli M, Taqueti V. Body Composition, Coronary Microvascular Dysfunction, and Future Risk of Cardiovascular Events Including Heart Failure. JACC Cardiovascular Imaging 2023, 17: 179-191. PMID: 37768241, PMCID: PMC10922555, DOI: 10.1016/j.jcmg.2023.07.014.Peer-Reviewed Original ResearchConceptsCoronary microvascular dysfunctionVisceral adipose tissueAssociated with coronary microvascular dysfunctionCoronary flow reserveBody mass indexLow coronary flow reserveSubcutaneous adipose tissueCoronary artery diseaseAdverse eventsPositron emission tomographyObese patientsMicrovascular dysfunctionVisceral adipose tissue cross-sectional areaCardiovascular eventsHeart failurePreserved left ventricular ejection fractionAdverse outcomesSkeletal muscleArtery diseaseFlow-limiting coronary artery diseaseBody compositionAssociated with body compositionEvaluation of coronary artery diseaseStress positron emission tomographyEmission tomography
2020
A current review of COVID-19 for the cardiovascular specialist
Lang J, Wang X, Moura F, Siddiqi H, Morrow D, Bohula E. A current review of COVID-19 for the cardiovascular specialist. American Heart Journal 2020, 226: 29-44. PMID: 32497913, PMCID: PMC7252118, DOI: 10.1016/j.ahj.2020.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine MonophosphateAlanineAntimalarialsAntiviral AgentsBetacoronavirusBiomarkersCardiovascular DiseasesChloroquineCoronavirus InfectionsCOVID-19HumansHydroxychloroquineHypoxiaPandemicsPlasmaPneumonia, ViralReceptor, Angiotensin, Type 2Risk FactorsSARS-CoV-2Takotsubo CardiomyopathyVirus InternalizationConceptsAcute cardiac injuryCardiac injuryAdverse outcomesLevels of cardiac troponinAssociated with adverse outcomesHyperinflammatory cytokine stormType 2 myocardial infarctionPre-existing cardiovascular diseaseLevel of suspicionComplications of COVID-19Stress-related cardiomyopathyIncreased blood levelsCardiovascular risk factorsNonischemic myocardial injurySevere COVID-19Cardiovascular complications of COVID-19Nonischemic causesTakotsubo syndromeNatriuretic peptideD-dimerHigher mortality riskCardiovascular complicationsDiffuse thrombosisInflammatory milieuMyocardial dysfunction
2017
Adverse outcome has a U-shaped relation with acute phase change in insulin sensitivity after ST-Elevation Myocardial Infarction
Moura F, Cintra R, Carvalho L, Santos S, Modolo R, Munhoz D, Quinaglia e Silva J, Coelho O, Nadruz W, Sposito A. Adverse outcome has a U-shaped relation with acute phase change in insulin sensitivity after ST-Elevation Myocardial Infarction. International Journal Of Cardiology 2017, 254: 16-22. PMID: 29246426, DOI: 10.1016/j.ijcard.2017.11.111.Peer-Reviewed Original ResearchConceptsST-elevation MIGRACE risk scoreInsulin sensitivity changesIntra-hospital deathMyocardial infarctionFollow-upMI hospitalizationAssociated with increased mortalityMarkers of glucose metabolismCox regression modelsInsulin provision therapyProspective cohortRisk scoreNet reclassification indexCardiac eventsAdverse cardiac eventsUpstream markersCox regressionAdverse outcomesHomeostasis model assessmentEstimate insulin sensitivityReclassification indexU-shaped relationStress hyperglycemiaInsulin sensitivity