2023
Metastatic Bladder Cancer Expression and Subcellular Localization of Nectin-4 and Trop-2 in Variant Histology: A Rapid Autopsy Study
Ghali F, Vakar-Lopez F, Roudier M, Garcia J, Arora S, Cheng H, Schweizer M, Haffner M, Lee J, Yu E, Grivas P, Montgomery B, Hsieh A, Wright J, Lam H. Metastatic Bladder Cancer Expression and Subcellular Localization of Nectin-4 and Trop-2 in Variant Histology: A Rapid Autopsy Study. Clinical Genitourinary Cancer 2023, 21: 669-678. PMID: 37344281, PMCID: PMC10674028, DOI: 10.1016/j.clgc.2023.05.014.Peer-Reviewed Original ResearchMeSH KeywordsAutopsyCarcinoma, Transitional CellHumansImmunoconjugatesNectinsRNA, MessengerUrinary Bladder NeoplasmsConceptsMetastatic urothelial carcinomaVariant histologySacituzumab govitecanTrop-2Nectin-4Antibody-drug conjugatesMetastatic lesionsADC targetCytoplasmic stainingProminent cytoplasmic stainingMembrane stainingTrop-2 expressionCytoplasmic protein expressionMetastatic sitesAutopsy studyUrothelial carcinomaMetastatic tumorsSquamous differentiationClinical relevanceCancer expressionHistologyNeuroendocrineProtein expressionMRNA levelsProtein levels
2019
Diagnosis, management, and follow-up of upper tract urothelial carcinoma: an interdisciplinary collaboration between urology and radiology
Roberts J, Ghali F, Aganovic L, Bechis S, Healy K, Rivera-Sanfeliz G, Autorino R, Derweesh I. Diagnosis, management, and follow-up of upper tract urothelial carcinoma: an interdisciplinary collaboration between urology and radiology. Abdominal Radiology 2019, 44: 3893-3905. PMID: 31701194, DOI: 10.1007/s00261-019-02293-9.Peer-Reviewed Original ResearchConceptsUpper tract urothelial carcinomaUrothelial carcinomaDevelopment of UTUCPost-operative surveillanceRadical extirpative surgeryHigh recurrence rateSpecific clinical situationsMorbid therapyInvasive workupUrothelial malignancyRecurrence rateExtirpative surgeryLethal malignancyNew patientsInvasive proceduresClinical situationsEndoscopic surgeryEnvironmental exposuresDiagnosisPatientsSurgeryCarcinomaMalignancyWorkupClose working relationship