Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer’s disease
Komaki H, Faraji N, Komaki A, Shahidi S, Etaee F, Raoufi S, Mirzaei F. Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer’s disease. Brain Research Bulletin 2019, 147: 14-21. PMID: 30721766, DOI: 10.1016/j.brainresbull.2019.01.025.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesAnimalsAntioxidantsDentate GyrusDisease Models, AnimalExcitatory Postsynaptic PotentialsHippocampusLong-Term PotentiationMaleMemoryMemory DisordersNeuronal PlasticityNeuroprotective AgentsOxidative StressPeptide FragmentsRatsRats, WistarSynaptic TransmissionTemporal LobeUbiquinoneConceptsLong-term potentiationAlzheimer's diseaseSynaptic plasticityAβ injectionAβ groupOral gavageQ10 treatmentRat modelCoenzyme Q10Adult male Wistar ratsExcitatory postsynaptic potential slopeTotal antioxidant capacity levelsHippocampal long-term potentiationΒ-amyloid depositionSerum malondialdehyde levelsHippocampal dentate gyrusMale rat modelHippocampal synaptic plasticityMale Wistar ratsEffects of AβHigh-frequency stimulationAntioxidant capacity levelsVivo electrophysiological recordingsTotal oxidant levelsPotential adverse consequences