Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats
Omidi G, Rezvani-Kamran A, Ganji A, Komaki S, Etaee F, Asadbegi M, Komaki A. Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats. The Journal Of Physiological Sciences 2020, 70: 19. PMID: 32209056, PMCID: PMC7093352, DOI: 10.1186/s12576-020-00747-0.Peer-Reviewed Original ResearchConceptsHigh-fat dietHigh-frequency stimulationExcitatory postsynaptic potentialsLong-term potentiationPerforant pathwayHypericum Scabrum extractSynaptic plasticityHFD groupPopulation spikesDentate gyrusEPSP slopePS amplitudeEffects of HFDField excitatory postsynaptic potentialsHigh-fat diet-fed ratsHippocampal synaptic plasticityMale Wistar ratsBipolar recording electrodesDiet-fed ratsDentate gyrus synaptic plasticityHippocampal neurogenesisNeuroprotective impactPostsynaptic potentialsWistar ratsControl group