2017
Leptin Is Produced by Parathyroid Glands and Stimulates Parathyroid Hormone Secretion
Hoang D, Broer N, Sosa JA, Abitbol N, Yao X, Li F, Rivera-Molina F, Toomre DK, Roman SA, Sue G, Kim S, Li AY, Callender GG, Simpson C, Narayan D. Leptin Is Produced by Parathyroid Glands and Stimulates Parathyroid Hormone Secretion. Annals Of Surgery 2017, 266: 1075-1083. PMID: 27611607, DOI: 10.1097/sla.0000000000002004.Peer-Reviewed Original ResearchConceptsParathyroid hormone secretionParathyroid glandsHormone secretionLeptin receptorOb/ob miceDiseased parathyroid glandsDiseased parathyroid tissueDiagnosis of hyperparathyroidismParathyroid chief cellsCultured parathyroid cellsAnimal model assaysJAK2/STAT3 inhibitorPTH levelsPTH secretionPTH releaseSerum calciumSitu hybridizationLeptin uptakeProspective studySurgical interventionConfocal microscopyHyperplastic glandsParathyroid tissueBone metabolismOb mice
2013
Leptin Signaling and Hyperparathyroidism: Clinical and Genetic Associations
Hoang D, Broer N, Roman SA, Yao X, Abitbol N, Li F, Sosa JA, Sue GR, DeWan AT, Wong ML, Licinio J, Simpson C, Li AY, Pizzoferrato N, Narayan D. Leptin Signaling and Hyperparathyroidism: Clinical and Genetic Associations. Journal Of The American College Of Surgeons 2013, 218: 1239-1250.e4. PMID: 24468228, DOI: 10.1016/j.jamcollsurg.2013.11.013.Peer-Reviewed Original ResearchConceptsParathyroid hormone levelsLeptin levelsParathyroid glandsHormone levelsBaseline leptin levelsLarge parathyroid glandsBody mass indexRole of leptinWilcoxon signed-rank testHyperplasia subgroupsParathyroid sizeObese patientsPostoperative changesMass indexParathyroid adenomaProspective studyParathyroid tissueBland-Altman methodLeptin productionSigned-rank testSurgical conditionsClinical studiesLeptin signalingLEPR polymorphismsLeptin