2024
The impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction
Hazan H, Ferrara M, Riley S, Li F, Zhou B, Kline E, Gibbs-Dean T, Karmani S, Tayfur S, Tek C, Keshavan M, Srihari V. The impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction. Schizophrenia Research 2024, 264: 457-461. PMID: 38266513, PMCID: PMC10923115, DOI: 10.1016/j.schres.2024.01.022.Peer-Reviewed Original ResearchMeSH KeywordsEarly DiagnosisHospitalizationHumansPsychotic DisordersSchizophrenic PsychologyTime FactorsConceptsCoordinated specialty careDuration of untreated psychosisImpact of early detectionEarly detectionEarly detection campaignsSpecialty careAdjustment scoresCampaign yearDetection campaignsMediation analysisEffects of EDRegression modelsCareUntreated psychosisPositive symptomsGAFPatientsSalutary effects
2023
The effect of duration of untreated psychosis (DUP) on the risk for hospitalization after admission to a first episode service
Ferrara M, Guloksuz S, Hazan H, Li F, Tek C, Sykes L, Riley S, Keshavan M, Srihari V. The effect of duration of untreated psychosis (DUP) on the risk for hospitalization after admission to a first episode service. Schizophrenia Research 2023, 260: 198-204. PMID: 37688984, DOI: 10.1016/j.schres.2023.08.005.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesLength of stayUntreated psychosisPsychiatric hospitalizationFirst-episode servicesDuration of hospitalizationIncidence rate ratiosNon-affective psychosisNew Haven areaPoisson regression modelsPatient characteristicsHospitalization ratesRecent onsetMedical recordsHospitalizationEffect of durationNegative binomial regressionSpecialized treatmentPsychosisRate ratioBinomial regressionAdmissionDUPEnrollmentFirst year
2022
DUP redux: Observations vs. experiments in early intervention (invited commentary on Nkire et al.)
Srihari V, Li F. DUP redux: Observations vs. experiments in early intervention (invited commentary on Nkire et al.). Schizophrenia Research 2022, 251: 46-48. PMID: 36565532, DOI: 10.1016/j.schres.2022.12.006.Peer-Reviewed Original Research
2021
First help-seeking attempt before and after psychosis onset: measures of delay and aversive pathways to care
Ferrara M, Guloksuz S, Mathis WS, Li F, Lin IH, Syed S, Gallagher K, Shah J, Kline E, Tek C, Keshavan M, Srihari VH. First help-seeking attempt before and after psychosis onset: measures of delay and aversive pathways to care. Social Psychiatry And Psychiatric Epidemiology 2021, 56: 1359-1369. PMID: 33948678, PMCID: PMC8319102, DOI: 10.1007/s00127-021-02090-0.Peer-Reviewed Original ResearchConceptsPsychosis onsetNon-affective psychosisPsychosis risk syndromeEarly detection effortsAversive eventsAversive pathwaysProdromal sampleClinical characteristicsAntipsychotic treatmentEffective treatmentSociodemographic characteristicsSpecialized treatmentPsychosisProdromeOnsetTreatmentStructured interviewsOverall functioningFamily membersMeasures of delayEpisodesNew HavenSemi-structured interviewsHelp seekersPathwayImplantable Cardioverter Defibrillator Lead Survival in Athletic Patients
Link MS, Sullivan RM, Olshansky B, Cannom D, Berul CI, Hauser RG, Heidbuchel H, Jordaens L, Krahn AD, Morgan J, Patton KK, Saarel EV, Wilkoff BL, Li F, Dziura J, Brandt C, Barth C, Lampert R. Implantable Cardioverter Defibrillator Lead Survival in Athletic Patients. Circulation Arrhythmia And Electrophysiology 2021, 14: e009344. PMID: 33724879, DOI: 10.1161/circep.120.009344.Peer-Reviewed Original Research
2017
Effects of Oral vs Transdermal Estrogen Therapy on Sexual Function in Early Postmenopause: Ancillary Study of the Kronos Early Estrogen Prevention Study (KEEPS)
Taylor HS, Tal A, Pal L, Li F, Black DM, Brinton EA, Budoff MJ, Cedars MI, Du W, Hodis HN, Lobo RA, Manson JE, Merriam GR, Miller VM, Naftolin F, Neal-Perry G, Santoro NF, Harman SM. Effects of Oral vs Transdermal Estrogen Therapy on Sexual Function in Early Postmenopause: Ancillary Study of the Kronos Early Estrogen Prevention Study (KEEPS). JAMA Internal Medicine 2017, 177: 1471-1479. PMID: 28846767, PMCID: PMC5710212, DOI: 10.1001/jamainternmed.2017.3877.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdministration, OralAdultDouble-Blind MethodEstradiolEstrogen Replacement TherapyEstrogensEstrogens, Conjugated (USP)FemaleFollow-Up StudiesGlucuronatesHumansMiddle AgedPostmenopauseProgesteroneProgestinsProspective StudiesPsychiatric Status Rating ScalesQuality of LifeRisk FactorsSexual Dysfunction, PhysiologicalTime FactorsWomen's HealthConceptsKronos Early Estrogen Prevention StudyLow sexual functionTransdermal estrogen therapySexual functionAncillary studiesEstrogen therapyPostmenopausal womenPrevention StudyT-E2Female Sexual Function InventoryOral conjugated equine estrogenOverall scoreLower FSFI scoresEarly postmenopausal womenMenopausal hormone therapyPlacebo-controlled trialOral micronized progesteroneConjugated equine estrogensSexual Function InventoryLast menstrual periodEffects of OralQuality of lifeProportion of womenSymptoms of distressMicronized progesterone
2016
Analyzing the Duration of Untreated Psychosis: Quantile Regression
Guloksuz S, Li F, Tek C, Woods SW, McGlashan TH, Friis S, Srihari VH. Analyzing the Duration of Untreated Psychosis: Quantile Regression. JAMA Psychiatry 2016, 73: 1094-1095. PMID: 27580422, DOI: 10.1001/jamapsychiatry.2016.2013.Peer-Reviewed Original Research
2014
Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study
Srihari VH, Tek C, Pollard J, Zimmet S, Keat J, Cahill JD, Kucukgoncu S, Walsh BC, Li F, Gueorguieva R, Levine N, Mesholam-Gately RI, Friedman-Yakoobian M, Seidman LJ, Keshavan MS, McGlashan TH, Woods SW. Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study. BMC Psychiatry 2014, 14: 335. PMID: 25471062, PMCID: PMC4262386, DOI: 10.1186/s12888-014-0335-3.Peer-Reviewed Original ResearchConceptsEarly detectionEarly outcomesGeographic catchmentTIPS studyYounger patientsAppropriate patientsUntreated psychosisPsychosis onsetEffective treatmentCare providersPsychotic symptomsPublic education campaignsPsychotic disordersHelp-seeking behaviorSecondary aimComprehensive interventionPatientsIntervention servicesDUPEducation campaignsOutcomesSocial marketing approachPrimary aimTreatmentFESRandomized Exercise Trial of Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors
Irwin ML, Cartmel B, Gross CP, Ercolano E, Li F, Yao X, Fiellin M, Capozza S, Rothbard M, Zhou Y, Harrigan M, Sanft T, Schmitz K, Neogi T, Hershman D, Ligibel J. Randomized Exercise Trial of Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors. Journal Of Clinical Oncology 2014, 33: 1104-1111. PMID: 25452437, PMCID: PMC4372849, DOI: 10.1200/jco.2014.57.1547.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsBrief Pain InventoryUsual careAromatase inhibitorsCancer survivorsPain scoresAromatase Inhibitor-Induced ArthralgiaInactive breast cancer survivorsMcMaster Universities Osteoarthritis IndexJoint pain scoresRandomized exercise trialWorst joint painPrimary end pointWOMAC pain scoreImpact of exerciseResistance training sessionAI adherenceOsteoarthritis IndexHand questionnaireJoint painPain severityPain InventoryExercise trialsAerobic exerciseWestern OntarioThe Temporal Kinetics of Circulating Angiopoietin Levels in Children With Sepsis
Giuliano JS, Tran K, Li FY, Shabanova V, Tala JA, Bhandari V. The Temporal Kinetics of Circulating Angiopoietin Levels in Children With Sepsis. Pediatric Critical Care Medicine 2014, 15: e1-e8. PMID: 24141659, PMCID: PMC3947338, DOI: 10.1097/pcc.0b013e3182a553bb.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAngiopoietin-1Angiopoietin-2BiomarkersCase-Control StudiesChildChild, PreschoolFemaleHumansIntensive Care Units, PediatricLength of StayMalePredictive Value of TestsProspective StudiesSepsisSeverity of Illness IndexShock, SepticSystemic Inflammatory Response SyndromeTime FactorsConceptsSevere sepsis/shockSepsis/shockSystemic inflammatory response syndrome/sepsisPediatric patientsShock groupAngiopoietin-2Day 2Angiopoietin-1Days of illnessHours of admissionIll pediatric patientsInflammatory response syndromeRisk stratification scoresProspective observational studyCritical care physiciansVascular growth factorsEnzyme-linked immunosorbentAngiopoietin levelsPICU lengthPICU patientsSevere sepsisSepsis severityResponse syndromeStratification scoresCare physicians
2013
Neutrophil CD64 with Hematologic Criteria for Diagnosis of Neonatal Sepsis
Streimish I, Bizzarro M, Northrup V, Wang C, Renna S, Koval N, Li FY, Ehrenkranz RA, Rinder HM, Bhandari V. Neutrophil CD64 with Hematologic Criteria for Diagnosis of Neonatal Sepsis. American Journal Of Perinatology 2013, 31: 021-030. PMID: 23456906, DOI: 10.1055/s-0033-1334453.Peer-Reviewed Original ResearchConceptsCulture-proven sepsisClinical sepsisNeutrophil CD64CD64 indexNeonatal sepsisHematologic criteriaSingle-centre neonatal intensive care unitEarly-onset clinical sepsisNeonatal intensive care unitNeutrophil CD64 indexProspective observational cohortAbsolute neutrophil countNormal birth weightIntensive care unitAbsolute band countNegative predictive valueAdditional markersSepsis evaluationNeutrophil countObservational cohortCare unitBirth weightHematologic parametersSepsisCD64