2013
Leptin Signaling and Hyperparathyroidism: Clinical and Genetic Associations
Hoang D, Broer N, Roman SA, Yao X, Abitbol N, Li F, Sosa JA, Sue GR, DeWan AT, Wong ML, Licinio J, Simpson C, Li AY, Pizzoferrato N, Narayan D. Leptin Signaling and Hyperparathyroidism: Clinical and Genetic Associations. Journal Of The American College Of Surgeons 2013, 218: 1239-1250.e4. PMID: 24468228, DOI: 10.1016/j.jamcollsurg.2013.11.013.Peer-Reviewed Original ResearchConceptsParathyroid hormone levelsLeptin levelsParathyroid glandsHormone levelsBaseline leptin levelsLarge parathyroid glandsBody mass indexRole of leptinWilcoxon signed-rank testHyperplasia subgroupsParathyroid sizeObese patientsPostoperative changesMass indexParathyroid adenomaProspective studyParathyroid tissueBland-Altman methodLeptin productionSigned-rank testSurgical conditionsClinical studiesLeptin signalingLEPR polymorphismsLeptin
2012
Insulin resistance is associated with elevated serum pigment epithelium–derived factor (PEDF) levels in morbidly obese patients
Gattu AK, Birkenfeld AL, Jornayvaz F, Dziura J, Li F, Crawford SE, Chu X, Still CD, Gerhard GS, Chung C, Samuel V. Insulin resistance is associated with elevated serum pigment epithelium–derived factor (PEDF) levels in morbidly obese patients. Acta Diabetologica 2012, 49: 161-169. PMID: 22547263, DOI: 10.1007/s00592-012-0397-y.Peer-Reviewed Original ResearchConceptsPigment epithelium-derived factorMorbidly obese patientsPEDF levelsInsulin resistanceDiabetes mellitusHigh glucose mediumObese patientsSerum pigment epithelium-derived factor (PEDF) levelsPigment epithelium-derived factor levelsSerum pigment epithelium-derived factorHomeostasis model assessment scoreCounter-regulatory factorsSerum PEDF concentrationGastric bypass surgeryHuman hepatocytesSignificant risk factorsModel assessment scoreSerum PEDF levelsEpithelium-derived factorPrimary human hepatocytesHOMA scorePEDF concentrationDiabetes medicationsGastric bypassIR patients