2018
Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice
Hu Y, Peng J, Li F, Wong FS, Wen L. Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice. Scientific Reports 2018, 8: 15451. PMID: 30337545, PMCID: PMC6193974, DOI: 10.1038/s41598-018-33571-z.Peer-Reviewed Original ResearchConceptsType 1 diabetesWeeks of ageGut microbiotaNOD miceVaginal microbiotaAuto-reactive T cellsNon-obese diabetic (NOD) micePeripheral blood mononuclear cellsInsulin-producing beta cellsFemale NOD miceProgressive autoimmune diseaseOnset of diabetesBlood mononuclear cellsDifferent mucosal sitesT1D developmentDiabetes onsetMucosal sitesDiabetes developmentDiabetic miceAutoimmune diseasesComposition of microbiotaMononuclear cellsT cellsMucosal microbiotaAdult mice
2010
Determinants of Individual Variation in Intracellular Accumulation of Anti-HIV Nucleoside Analog Metabolites
Paintsil E, Dutschman GE, Hu R, Grill SP, Wang CJ, Lam W, Li FY, Ghebremichael M, Northrup V, Cheng YC. Determinants of Individual Variation in Intracellular Accumulation of Anti-HIV Nucleoside Analog Metabolites. Antimicrobial Agents And Chemotherapy 2010, 55: 895-903. PMID: 21078952, PMCID: PMC3028801, DOI: 10.1128/aac.01303-10.Peer-Reviewed Original ResearchConceptsNucleoside analoguesPeripheral blood mononuclear cellsAntiretroviral drug discoveryThymidine kinase 1 activityBlood mononuclear cellsConcentrations of AZTMetabolite concentrationsIntracellular concentrationAntiretroviral therapyClinical responseMononuclear cellsHealthy donorsHIV therapyTherapy needTriphosphate metaboliteAZT monophosphateAnalogue metabolitesCellular kinasesCassette (ABC) transport proteinsInverse correlationDemographic characteristicsAZTIntracellular accumulationKinase 1 activityIndividual variation