Firework-related injuries treated at emergency departments in the United States during the COVID-19 pandemic in 2020 compared to 2018–2019
Maassel N, Saccary A, Solomon D, Stitelman D, Xu Y, Li F, Christison-Lagay E, Dodington J. Firework-related injuries treated at emergency departments in the United States during the COVID-19 pandemic in 2020 compared to 2018–2019. Injury Epidemiology 2021, 8: 65. PMID: 34758871, PMCID: PMC8579722, DOI: 10.1186/s40621-021-00358-2.Peer-Reviewed Original ResearchNational Electronic Injury Surveillance SystemFireworks-related injuriesEmergency departmentElectronic Injury Surveillance SystemNational estimatesConsumer Product Safety Commission dataInjury Surveillance SystemCOVID-19 pandemicStudy inclusionInjury informationInjuryMonthly injurySame time periodUS Census dataNational decreaseMonthsSurveillance systemConsumer fireworksUnited StatesProportional increaseYearsDepartmentPandemicResultsThereEpidemiologyPazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3
Yuan Q, Basit A, Liang W, Qu R, Luan Y, Ren C, Li A, Xu X, Liu X, Yang C, Kuo A, Pierce R, Zhang L, Turk B, Hu X, Li F, Cui W, Li R, Huang D, Mo L, Sessa WC, Lee PJ, Kluger Y, Su B, Tang W, He J, Wu D. Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3. Science Translational Medicine 2021, 13 PMID: 33910977, PMCID: PMC8466683, DOI: 10.1126/scitranslmed.abc2499.Peer-Reviewed Original ResearchConceptsAcute lung injuryLung injuryMyeloid cellsLung transplantation recipientsMouse ALI modelPulmonary barrier functionTransplantation recipientsALI modelReactive oxygen species formationPharmacological interventionsPazopanibOxygen species formationVasculature integrityEpithelial cell survivalHigh mortalityMitogen-activated protein kinase kinase kinase 2Barrier functionGenetic inactivationInjuryCell survivalMortalityProtein kinase kinase kinase 2MAP3K3Kinase 2Manifestations