2010
A brighter side of ROS revealed by selective activation of β‐adrenergic receptor subtypes
Biary N, Akar FG. A brighter side of ROS revealed by selective activation of β‐adrenergic receptor subtypes. The Journal Of Physiology 2010, 588: 2973-2974. PMID: 20710039, PMCID: PMC2956937, DOI: 10.1113/jphysiol.2010.195743.Commentaries, Editorials and LettersAdrenergic beta-1 Receptor AgonistsAdrenergic beta-2 Receptor AgonistsAnimalsGTP-Binding Protein alpha Subunits, Gi-GoHomeostasisHumansMyocytes, CardiacNitric OxideNitric Oxide Synthase Type IIIOxygenRatsReactive Oxygen SpeciesReceptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2Signal Transduction
2009
Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy
Aiba T, Hesketh GG, Barth AS, Liu T, Daya S, Chakir K, Dimaano VL, Abraham TP, O'Rourke B, Akar FG, Kass DA, Tomaselli GF. Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy. Circulation 2009, 119: 1220-1230. PMID: 19237662, PMCID: PMC2703676, DOI: 10.1161/circulationaha.108.794834.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBundle-Branch BlockCalciumCalcium ChannelsCoronary CirculationDogsEchocardiographyElectrocardiographyHeart FailureHomeostasisKv Channel-Interacting ProteinsMaleMyocytes, CardiacPacemaker, ArtificialPatch-Clamp TechniquesPotassium Channels, Inwardly RectifyingRNA, MessengerSarcoplasmic Reticulum Calcium-Transporting ATPasesShal Potassium ChannelsConceptsCardiac resynchronization therapyAction potential durationRight atrial pacingCalcium transient amplitudeHeart failurePotential durationResynchronization therapyAtrial pacingElectrophysiological consequencesLeft bundle-branch ablationTransient amplitudeSarcoplasmic reticulumWhole-cell patch clampDyssynchronous heart failureProtein levelsIon channel remodelingSame pacing rateLeft ventricular anteriorQuantitative polymerase chain reactionSurvival benefitBiventricular pacingVentricular arrhythmiasDyssynchronous contractionPolymerase chain reactionElectrophysiological changes