2013
Electrophysiological Remodeling in Heart Failure
Akar F, Tomaselli G. Electrophysiological Remodeling in Heart Failure. 2013, 369-386. DOI: 10.1007/978-1-4471-4881-4_22.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHeart failureTreatment of arrhythmiasCellular electrophysiological propertiesIon channelsSafe therapyConduction abnormalitiesElectrophysiological remodelingSudden deathNovel pharmacologicalArrhythmogenic triggersElectrophysiological propertiesAction potentialsArrhythmiasFunctional consequencesIonic mechanismsMolecular mechanismsOrgan levelFailureTherapyAbnormalitiesPharmacologicalRepolarization
2005
Conduction Abnormalities in Nonischemic Dilated Cardiomyopathy: Basic Mechanisms and Arrhythmic Consequences
Akar FG, Tomaselli GF. Conduction Abnormalities in Nonischemic Dilated Cardiomyopathy: Basic Mechanisms and Arrhythmic Consequences. Trends In Cardiovascular Medicine 2005, 15: 259-264. PMID: 16226681, DOI: 10.1016/j.tcm.2005.08.002.Peer-Reviewed Original ResearchConceptsConduction abnormalitiesVentricular dysfunctionHeart failureMolecular mechanismsLeft ventricular dysfunctionNonischemic heart failureIschemic heart diseaseExtracellular matrixGenesis of arrhythmiasMyocyte excitabilityMechanistic differencesOrgan levelMembrane excitabilityVentricular tachyarrhythmiasDisease etiologyMyocardial infarctionHeart diseaseArrhythmogenic substrateSudden deathArrhythmic consequencesCell couplingAbnormalitiesBasic mechanismsDysfunctionExcitability