2022
Humanized Dsp ACM Mouse Model Displays Stress-Induced Cardiac Electrical and Structural Phenotypes
Stevens TL, Manring HR, Wallace MJ, Argall A, Dew T, Papaioannou P, Antwi-Boasiako S, Xu X, Campbell SG, Akar FG, Borzok MA, Hund TJ, Mohler PJ, Koenig SN, El Refaey M. Humanized Dsp ACM Mouse Model Displays Stress-Induced Cardiac Electrical and Structural Phenotypes. Cells 2022, 11: 3049. PMID: 36231013, PMCID: PMC9562631, DOI: 10.3390/cells11193049.Peer-Reviewed Original ResearchConceptsArrhythmogenic cardiomyopathyMouse modelStructural phenotypesFibro-fatty infiltrationFirst mouse modelHeart failureChamber dilationVentricular arrhythmiasPressure overloadArrhythmic eventsCardiac performanceCardiac stressSudden deathCardiovascular stressInherited disorderG variantConnexin 43MiceDesmosomal genesReduced expressionExternal stressorsACM familyDisease developmentMurine equivalentIncomplete penetrance
2011
Alterations in Mitochondrial State 4→3 Transition Underlie Stress-Induced Energetic-Redox Imbalance and Myocyte Dysfunction in Diabetic Mice
Tocchetti C, Stanley B, Shi S, Watson W, Cortassa S, Akar F, Paolocci N, Aon M. Alterations in Mitochondrial State 4→3 Transition Underlie Stress-Induced Energetic-Redox Imbalance and Myocyte Dysfunction in Diabetic Mice. Biophysical Journal 2011, 100: 292a. DOI: 10.1016/j.bpj.2010.12.1795.Peer-Reviewed Original Research