2005
Molecular Basis of Arrhythmias
Shah M, Akar FG, Tomaselli GF. Molecular Basis of Arrhythmias. Circulation 2005, 112: 2517-2529. PMID: 16230503, DOI: 10.1161/circulationaha.104.494476.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIon channel subunit genesChannel subunit genesSubunit geneMolecular basisBasic biologySingle gene disordersNew molecular targetsCardiac arrhythmiasCellular basisGene disordersMolecular targetsMolecular pathogenesisPathophysiological conditionsCritical roleCatecholaminergic polymorphic ventricular tachycardiaPrimary electrical diseasePathological remodelingFundamental mechanismsPolymorphic ventricular tachycardiaImportant insightsLong QT syndromeElectrical diseaseVentricular tachycardiaBrugada syndromeGenes
2002
Unique Topographical Distribution of M Cells Underlies Reentrant Mechanism of Torsade de Pointes in the Long-QT Syndrome
Akar FG, Yan GX, Antzelevitch C, Rosenbaum DS. Unique Topographical Distribution of M Cells Underlies Reentrant Mechanism of Torsade de Pointes in the Long-QT Syndrome. Circulation 2002, 105: 1247-1253. PMID: 11889021, DOI: 10.1161/hc1002.105231.Peer-Reviewed Original ResearchConceptsLong QT syndromeSpecific ion channel mutationsCongenital long QT syndromeM cellsQT interval prolongationIon channel mutationsInterval prolongationReentrant mechanismTdP arrhythmiasConduction blockCanine wedge preparationReentrant circuitTransmural dispersionLeft ventricleAction potentialsTransmural wallIntact myocardiumTopographical distributionChannel mutationsWedge preparationsMidmyocardial cellsRepolarizationLQT2Cellular basisElectrical instability