2017
Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
Karam BS, Chavez-Moreno A, Koh W, Akar JG, Akar FG. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovascular Diabetology 2017, 16: 120. PMID: 28962617, PMCID: PMC5622555, DOI: 10.1186/s12933-017-0604-9.Peer-Reviewed Original ResearchConceptsAtrial fibrillationOxidative stressCommon sustained cardiac arrhythmiaMaintenance of AFSustained cardiac arrhythmiaDiabetic heartElectrical remodelingRisk factorsAtrial excitabilityTherapeutic strategiesCardiac arrhythmiasInflammationCentral mediatorObesityDiabetesFibrillationMechanistic linkMellitusArrhythmiasExcitability
2005
Molecular Basis of Arrhythmias
Shah M, Akar FG, Tomaselli GF. Molecular Basis of Arrhythmias. Circulation 2005, 112: 2517-2529. PMID: 16230503, DOI: 10.1161/circulationaha.104.494476.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIon channel subunit genesChannel subunit genesSubunit geneMolecular basisBasic biologySingle gene disordersNew molecular targetsCardiac arrhythmiasCellular basisGene disordersMolecular targetsMolecular pathogenesisPathophysiological conditionsCritical roleCatecholaminergic polymorphic ventricular tachycardiaPrimary electrical diseasePathological remodelingFundamental mechanismsPolymorphic ventricular tachycardiaImportant insightsLong QT syndromeElectrical diseaseVentricular tachycardiaBrugada syndromeGenes
2004
Ionic mechanisms of cardiac arrhythmias
Akar F, Tomaselli G. Ionic mechanisms of cardiac arrhythmias. Drug Discovery Today Disease Mechanisms 2004, 1: 23-30. DOI: 10.1016/j.ddmec.2004.08.005.ChaptersIndividual cardiac myocytesArrhythmia controlCardiac arrhythmiasIntricate vascular networkDuke University Medical CenterCardiac myocytesGood arrhythmia controlSudden cardiac death casesCardiac death casesUniversity Medical CenterIonic mechanismsGenetic risk factorsPascal J. Goldschmidt-ClermontGlobal electrical activityCardiovascular deathAbnormal heart rhythmMalignant arrhythmiasDrug therapyRhythm disturbancesHeart diseaseRisk factorsMedical CenterTherapeutic strategiesArrhythmia syndromesCardiac chambers
1998
Modulated Dispersion Explains Changes in Arrhythmia Vulnerability During Premature Stimulation of the Heart
Laurita K, Girouard S, Akar F, Rosenbaum D. Modulated Dispersion Explains Changes in Arrhythmia Vulnerability During Premature Stimulation of the Heart. Circulation 1998, 98: 2774-2780. PMID: 9851966, DOI: 10.1161/01.cir.98.24.2774.Peer-Reviewed Original ResearchConceptsVentricular fibrillation thresholdSingle premature stimulusPremature stimuliArrhythmia vulnerabilityBaseline levelsPremature stimulationS1S2 intervalRepolarization gradientsGuinea pig heartsBaseline pacingFibrillation thresholdArrhythmogenic substrateVentricular fibrillationVentricular sitesStimulus-induced changesVentricular repolarizationCoupling intervalCardiac arrhythmiasS2 beatElectrophysiological propertiesAction potentialsOptical action potentialsHeterogeneous electrophysiological propertiesPig heartsRepolarization