2022
Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments
Yang M, Wang X, Guan F, Titt U, Iga K, Jiang D, Takaoka T, Tootake S, Katayose T, Umezawa M, Schüler E, Frank S, Lin SH, Sahoo N, Koong AC, Mohan R, Zhu XR. Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments. Physics In Medicine And Biology 2022, 67: 165002. PMID: 35853442, PMCID: PMC9422888, DOI: 10.1088/1361-6560/ac8269.Peer-Reviewed Original ResearchConceptsAdvanced Markus chamberProton beamlineEBT-XD filmsMarkus chamberIrradiation conditionsUltra-high dose ratesUnique time structureFLASH irradiationAverage dose rateAbsolute dose calibrationDose rateBeamlineDose calibrationFlash experimentsTime structureAbsolute doseIrradiation platformMonte Carlo simulationsFLASH effectField sizeFlash conditionsDose controlGy sPrecise dosimetryCarlo simulations
2021
Uncertainty in tissue equivalent proportional counter assessments of microdosimetry and RBE estimates in carbon radiotherapy
Hartzell S, Guan F, Taylor P, Peterson C, Taddei P, Kry S. Uncertainty in tissue equivalent proportional counter assessments of microdosimetry and RBE estimates in carbon radiotherapy. Physics In Medicine And Biology 2021, 66: 155018. PMID: 34252894, DOI: 10.1088/1361-6560/ac1366.Peer-Reviewed Original ResearchConceptsTissue equivalent proportional counterCommon mathematical modelPerturbed valuesMicrodosimetric kinetic modelLow-energy cutMonte Carlo toolkitMathematical modelCounting statisticsCentral beam axisEnergy deposition distributionsStatistic uncertaintyInput parametersTherapeutic carbon beamsLineal energy valuesCarbon beamBeam axisTEPC measurementsSources of uncertaintyWall effectsModel input parametersMicrodosimetric spectraInherent uncertaintyRelative biological effectivenessUncertaintyCarbon radiotherapy
2017
Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams
Patel D, Bronk L, Guan F, Peeler CR, Brons S, Dokic I, Abdollahi A, Rittmüller C, Jäkel O, Grosshans D, Mohan R, Titt U. Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams. Medical Physics 2017, 44: 6061-6073. PMID: 28880368, DOI: 10.1002/mp.12568.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorHumansMonte Carlo MethodRadiometryRelative Biological EffectivenessUncertainty
2015
Calculations of S values and effective dose for the radioiodine carrier and surrounding individuals based on Chinese hybrid reference phantoms using the Monte Carlo technique
Geng C, Tang X, Qian W, Guan F, Johns J, Yu H, Gong C, Shu D, Chen D. Calculations of S values and effective dose for the radioiodine carrier and surrounding individuals based on Chinese hybrid reference phantoms using the Monte Carlo technique. Journal Of Radiological Protection 2015, 35: 707-717. PMID: 26344387, DOI: 10.1088/0952-4746/35/3/707.Peer-Reviewed Original ResearchGEANT4 calculations of neutron dose in radiation protection using a homogeneous phantom and a Chinese hybrid male phantom
Geng C, Tang X, Guan F, Johns J, Vasudevan L, Gong C, Shu D, Chen D. GEANT4 calculations of neutron dose in radiation protection using a homogeneous phantom and a Chinese hybrid male phantom. Radiation Protection Dosimetry 2015, 168: 433-440. PMID: 26156875, DOI: 10.1093/rpd/ncv364.Peer-Reviewed Original ResearchConceptsNeutron dose calculationsDepth dose distributionsHomogeneous phantomThermal energy rangeS-matrix correctionsClose simulation resultsPhysics listsGeant4 calculationsNeutron energyEnergy rangeThermal scatteringNeutron doseRadiation protectionGeant4Conversion coefficientsMCNP5Dose conversion coefficientsDose distributionDose calculationsMatrix correctionMale phantomPhantomCalculationsEnergyFluenceA Novel Algorithm for Solving the True Coincident Counting Issues in Monte Carlo Simulations for Radiation Spectroscopy
Guan F, Johns JM, Vasudevan L, Zhang G, Tang X, Poston JW, Braby LA. A Novel Algorithm for Solving the True Coincident Counting Issues in Monte Carlo Simulations for Radiation Spectroscopy. Health Physics 2015, 108: 574-579. PMID: 25905518, DOI: 10.1097/hp.0000000000000185.Peer-Reviewed Original ResearchConceptsHigh-purity germanium detectorDetection efficiencyRadiation spectroscopyGermanium detectorCoincident countsGeant4 Monte Carlo simulation toolkitSimulated pulse height spectraMonte Carlo simulation toolkitPulse height spectraRadiation fieldRadiation sourceCoincident radiationNuclear fissionHeight spectraMonte Carlo methodSource particlesSimulation toolkitSpectroscopy problemsMonte Carlo simulationsDetectorCarlo methodCarlo simulationsSpectroscopySpectraNuclear fuel