2022
Optimization of FLASH proton beams using a track‐repeating algorithm
Wang Q, Titt U, Mohan R, Guan F, Zhao Y, Yang M, Yepes P. Optimization of FLASH proton beams using a track‐repeating algorithm. Medical Physics 2022, 49: 6684-6698. PMID: 35900902, DOI: 10.1002/mp.15849.Peer-Reviewed Original ResearchRoadmap: helium ion therapy
Mairani A, Mein S, Blakely E, Debus J, Durante M, Ferrari A, Fuchs H, Georg D, Grosshans DR, Guan F, Haberer T, Harrabi S, Horst F, Inaniwa T, Karger CP, Mohan R, Paganetti H, Parodi K, Sala P, Schuy C, Tessonnier T, Titt U, Weber U. Roadmap: helium ion therapy. Physics In Medicine And Biology 2022, 67: 15tr02. PMID: 35395649, DOI: 10.1088/1361-6560/ac65d3.Peer-Reviewed Original ResearchConceptsHelium ion beamHeavy ion therapyIon beam therapyHelium ionsIon beamIon therapyRelative biological effectivenessHeavy ion beamsLawrence Berkeley National LaboratoryCarbon ion beamsHelium ion therapyDifferent particle speciesBerkeley National LaboratoryClinical proton beamsCarbon ion therapyLinear energy transferHigh relative biological effectivenessSharp lateral penumbraHigh penetration depthLateral scatteringNeon ionsBeam therapyProton beamParticle speciesTerms of physicsAdaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments
Yang M, Wang X, Guan F, Titt U, Iga K, Jiang D, Takaoka T, Tootake S, Katayose T, Umezawa M, Schüler E, Frank S, Lin SH, Sahoo N, Koong AC, Mohan R, Zhu XR. Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments. Physics In Medicine And Biology 2022, 67: 165002. PMID: 35853442, PMCID: PMC9422888, DOI: 10.1088/1361-6560/ac8269.Peer-Reviewed Original ResearchConceptsAdvanced Markus chamberProton beamlineEBT-XD filmsMarkus chamberIrradiation conditionsUltra-high dose ratesUnique time structureFLASH irradiationAverage dose rateAbsolute dose calibrationDose rateBeamlineDose calibrationFlash experimentsTime structureAbsolute doseIrradiation platformMonte Carlo simulationsFLASH effectField sizeFlash conditionsDose controlGy sPrecise dosimetryCarlo simulations
2019
Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness
Newpower M, Patel D, Bronk L, Guan F, Chaudhary P, McMahon SJ, Prise KM, Schettino G, Grosshans DR, Mohan R. Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness. International Journal Of Radiation Oncology • Biology • Physics 2019, 104: 316-324. PMID: 30731186, PMCID: PMC6499683, DOI: 10.1016/j.ijrobp.2019.01.094.Peer-Reviewed Original ResearchConceptsProton energy spectraMicrodosimetric kinetic modelDose-mean lineal energyRelative biological effectivenessProton irradiation experimentsEnergy spectrumLineal energyLineal energy yIrradiation experimentsLineal energy distributionsDose-averaged linear energy transferBiological effectivenessDifferent proton energiesLinear energy transferRBE modelsProton energyBragg curveEnergy distributionGeant4-DNAProton irradiationRBE data
2018
Power-law relationship in the long-tailed sections of proton dose distributions
Jiang B, Wang X, Zhang Y, Guan F, Li Y, Wang X, Zhu RX, Zhang X. Power-law relationship in the long-tailed sections of proton dose distributions. Scientific Reports 2018, 8: 10413. PMID: 29991734, PMCID: PMC6039508, DOI: 10.1038/s41598-018-28683-5.Peer-Reviewed Original ResearchConceptsIndirect impact mechanismMathematical modelDose distributionPower-law exponentLateral dose distributionProton dose distributionsStatistical methodsImpact probabilityPower law relationshipDirect impact mechanismHalo portionDose profilesDose depositionExperimental dataLong tailProbabilityDistributionProton impactExponent