2022
Roadmap: helium ion therapy
Mairani A, Mein S, Blakely E, Debus J, Durante M, Ferrari A, Fuchs H, Georg D, Grosshans DR, Guan F, Haberer T, Harrabi S, Horst F, Inaniwa T, Karger CP, Mohan R, Paganetti H, Parodi K, Sala P, Schuy C, Tessonnier T, Titt U, Weber U. Roadmap: helium ion therapy. Physics In Medicine And Biology 2022, 67: 15tr02. PMID: 35395649, DOI: 10.1088/1361-6560/ac65d3.Peer-Reviewed Original ResearchConceptsHelium ion beamHeavy ion therapyIon beam therapyHelium ionsIon beamIon therapyRelative biological effectivenessHeavy ion beamsLawrence Berkeley National LaboratoryCarbon ion beamsHelium ion therapyDifferent particle speciesBerkeley National LaboratoryClinical proton beamsCarbon ion therapyLinear energy transferHigh relative biological effectivenessSharp lateral penumbraHigh penetration depthLateral scatteringNeon ionsBeam therapyProton beamParticle speciesTerms of physics
2020
Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques
Bronk L, Guan F, Patel D, Ma D, Kroger B, Wang X, Tran K, Yiu J, Stephan C, Debus J, Abdollahi A, Jäkel O, Mohan R, Titt U, Grosshans DR. Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques. Cancers 2020, 12: 3658. PMID: 33291477, PMCID: PMC7762185, DOI: 10.3390/cancers12123658.Peer-Reviewed Original ResearchHeidelberg Ion Beam Therapy CenterRelative biological effectivenessCarbon ionsDose-mean lineal energyDose-averaged linear energy transferBiological effectivenessLinear energy transferMonte Carlo systemHelium ionsParticle beamsLineal energyBeam pathBragg peakMaximum relative biological effectivenessEnergy transferProtonsHeliumIonsTherapy CenterBeamExperimental platformSpatial distributionEnergyExperimental resultsSub
2016
Monte Carlo simulations of 3He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness
Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Monte Carlo simulations of 3He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness. Medical Physics 2016, 43: 761-776. PMID: 26843239, DOI: 10.1118/1.4939440.Peer-Reviewed Original ResearchConceptsMonte Carlo codeEnergy depositionCarlo codeLineal energyEnergy distributionRadiation beam qualitiesSecondary particle productionDifferent Monte Carlo codesDepth dose curvesPrimary beam parametersGaussian energy distributionMonte Carlo systemHelium ionsBeam qualityMicrodosimetric parametersMonte Carlo methodBeam parametersEnergy spectrumIncident beamBragg curveRadiobiological effectivenessBragg peakHalf maximumProton doseFull width
2014
TH‐A‐19A‐05: Modeling Physics Properties and Biologic Effects Induced by Proton and Helium Ions
Taleei R, Titt U, Peeler C, Guan F, Mirkovic D, Grosshans D, Mohan R. TH‐A‐19A‐05: Modeling Physics Properties and Biologic Effects Induced by Proton and Helium Ions. Medical Physics 2014, 41: 534-534. DOI: 10.1118/1.4889538.Peer-Reviewed Original ResearchMonte Carlo codeFragmentation cross sectionsHelium ionsBragg peakCarlo codeCross sectionsGeneral purpose Monte Carlo codeLight ionsMicrodosimetric parametersProton beamEnergy spectrumCarbon ionsBragg curveDepth dosePhysics propertiesWater phantomPhysical propertiesRBE increasesProtonsMonte Carlo simulationsDose distributionFLUKABeamIonsCurve calculations
2013
SU‐E‐T‐535: On the Out‐Of‐Field‐Doses Caused by Secondary Particles From Light Ion Beams in Charged Particle Therapy
Titt U, Guan F, Mirkovic D, Mohan R. SU‐E‐T‐535: On the Out‐Of‐Field‐Doses Caused by Secondary Particles From Light Ion Beams in Charged Particle Therapy. Medical Physics 2013, 40: 328-328. DOI: 10.1118/1.4814965.Peer-Reviewed Original ResearchLight ion beamsIon beamSecondary particlesLateral dose distributionSource particlesTherapeutic ion beamsLateral dose profilesHeavy ionsHelium ionsBeam parametersNuclear reactionsLateral doseDose depositionEnergy depositionHeavy particlesIon therapyParticle speciesBragg peakCharged Particle TherapyDose profilesWater phantomTarget fragmentationParticle therapyModulation widthPrimary particles