2020
Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques
Bronk L, Guan F, Patel D, Ma D, Kroger B, Wang X, Tran K, Yiu J, Stephan C, Debus J, Abdollahi A, Jäkel O, Mohan R, Titt U, Grosshans DR. Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques. Cancers 2020, 12: 3658. PMID: 33291477, PMCID: PMC7762185, DOI: 10.3390/cancers12123658.Peer-Reviewed Original ResearchHeidelberg Ion Beam Therapy CenterRelative biological effectivenessCarbon ionsDose-mean lineal energyDose-averaged linear energy transferBiological effectivenessLinear energy transferMonte Carlo systemHelium ionsParticle beamsLineal energyBeam pathBragg peakMaximum relative biological effectivenessEnergy transferProtonsHeliumIonsTherapy CenterBeamExperimental platformSpatial distributionEnergyExperimental resultsSubExploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Scientific Reports 2020, 10: 3199. PMID: 32081928, PMCID: PMC7035246, DOI: 10.1038/s41598-020-60246-5.Peer-Reviewed Original ResearchConceptsIntensity-modulated proton therapyLow-energy beamsIntensity modulation patternCurrent treatment planProton therapyBiological effectsDelivery strategiesTarget doseTherapeutic indexTreatment planHigh-energy beamsEffective doseEnhanced biological effectClinical potentialTherapyCancer cellsDoseBragg peak
2018
Physical parameter optimization scheme for radiobiological studies of charged particle therapy
Geng C, Gates D, Bronk L, Ma D, Guan F. Physical parameter optimization scheme for radiobiological studies of charged particle therapy. Physica Medica 2018, 51: 13-21. PMID: 30278981, PMCID: PMC6173200, DOI: 10.1016/j.ejmp.2018.06.001.Peer-Reviewed Original ResearchConceptsIon beamParticle therapyPhysical quantitiesDose-averaged linear energy transferC-ion beamsLinear energy transferBiological dose optimizationParticle beamsProton beamBragg curveBragg peakWhole target regionBeamCorresponding physical dataEnergy transferProtonsMonte Carlo simulationsAppropriate biophysical modelSpatial distributionSOBPRadiobiological studiesCarlo simulationsDose spreadIonsLETInvestigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy.
Shao W, Tang X, Bai Y, Shu D, Geng C, Gong C, Guan F. Investigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy. Journal Of Cancer Research And Therapeutics 2018, 14: 184-195. PMID: 29516984, DOI: 10.4103/jcrt.jcrt_1349_16.Peer-Reviewed Original ResearchConceptsT transverse magnetic fieldBeam energyCarbon ion beamsTherapeutic beamTransverse magnetic fieldMagnetic fieldDose perturbationsDose perturbation effectsIon beamMagnetic resonance imaging-guided radiotherapyHigher beam energiesUniform magnetic fieldWater-air interfaceAir-tissue interfacePhoton beamsRadiation fieldPerturbation effectsBragg peakProper energyBeamBeam typeDose distributionEnergyProtonsRadiotherapy methods
2016
Monte Carlo simulations of 3He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness
Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Monte Carlo simulations of 3He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness. Medical Physics 2016, 43: 761-776. PMID: 26843239, DOI: 10.1118/1.4939440.Peer-Reviewed Original ResearchConceptsMonte Carlo codeEnergy depositionCarlo codeLineal energyEnergy distributionRadiation beam qualitiesSecondary particle productionDifferent Monte Carlo codesDepth dose curvesPrimary beam parametersGaussian energy distributionMonte Carlo systemHelium ionsBeam qualityMicrodosimetric parametersMonte Carlo methodBeam parametersEnergy spectrumIncident beamBragg curveRadiobiological effectivenessBragg peakHalf maximumProton doseFull width
2014
TH‐A‐19A‐05: Modeling Physics Properties and Biologic Effects Induced by Proton and Helium Ions
Taleei R, Titt U, Peeler C, Guan F, Mirkovic D, Grosshans D, Mohan R. TH‐A‐19A‐05: Modeling Physics Properties and Biologic Effects Induced by Proton and Helium Ions. Medical Physics 2014, 41: 534-534. DOI: 10.1118/1.4889538.Peer-Reviewed Original ResearchMonte Carlo codeFragmentation cross sectionsHelium ionsBragg peakCarlo codeCross sectionsGeneral purpose Monte Carlo codeLight ionsMicrodosimetric parametersProton beamEnergy spectrumCarbon ionsBragg curveDepth dosePhysics propertiesWater phantomPhysical propertiesRBE increasesProtonsMonte Carlo simulationsDose distributionFLUKABeamIonsCurve calculations
2013
SU‐E‐T‐502: In Search of the Optimum Ion for Radiotherapy
Guan F, Titt U, Bangert M, Mohan R. SU‐E‐T‐502: In Search of the Optimum Ion for Radiotherapy. Medical Physics 2013, 40: 320-320. DOI: 10.1118/1.4814931.Peer-Reviewed Original ResearchFragmentation tailC ionsBragg peakGeant4 Monte Carlo toolkitMonte Carlo toolkitC-ion beamsLateral penumbraPeak dose ratioNarrow Bragg peaksMonoenergetic beamsTypes of ionsIon beamEnergy dependenceBroad beamLET distributionsPristine beamWater phantomNuclear fragmentsBeamDose contributionSpatial doseDifferent ionsProtonsSmaller penumbraIonsSU‐E‐T‐535: On the Out‐Of‐Field‐Doses Caused by Secondary Particles From Light Ion Beams in Charged Particle Therapy
Titt U, Guan F, Mirkovic D, Mohan R. SU‐E‐T‐535: On the Out‐Of‐Field‐Doses Caused by Secondary Particles From Light Ion Beams in Charged Particle Therapy. Medical Physics 2013, 40: 328-328. DOI: 10.1118/1.4814965.Peer-Reviewed Original ResearchLight ion beamsIon beamSecondary particlesLateral dose distributionSource particlesTherapeutic ion beamsLateral dose profilesHeavy ionsHelium ionsBeam parametersNuclear reactionsLateral doseDose depositionEnergy depositionHeavy particlesIon therapyParticle speciesBragg peakCharged Particle TherapyDose profilesWater phantomTarget fragmentationParticle therapyModulation widthPrimary particles