2024
Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regions
2021
Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain
Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched‐chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain. Epilepsia 2021, 62: e88-e97. PMID: 33949690, PMCID: PMC11259155, DOI: 10.1111/epi.16920.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acids, Branched-ChainBrain ChemistryChildChild, PreschoolChromatography, High Pressure LiquidDrug Resistant EpilepsyElectrocorticographyElectroencephalographyEpilepsies, PartialExtracellular SpaceFemaleGlutamic AcidHumansIsoleucineMaleMicrodialysisMiddle AgedSeizuresTandem Mass SpectrometryYoung AdultConceptsSpontaneous seizuresDrug-resistant focal epilepsyExtracellular brain glutamateHuman epileptic brainBranched-chain amino acidsBranched chain amino acids valineRefractory epilepsyBrain microdialysisGlutamatergic neurotransmissionFocal epilepsySeizure onsetBrain glutamateEpileptic brainHuman patientsSeizuresBrain regionsDialysis samplesMammalian targetEpilepsyLiquid chromatography-tandem mass spectrometryBaselineBCAAIntracranial electroencephalographyChromatography-tandem mass spectrometryPatients
2020
Case Report: Suprasellar Pituitary Adenoma Presenting With Temporal Lobe Seizures
Hong CS, Gorrepati R, Kundishora AJ, Elsamadicy AA, Peter PR, Damisah EC, Manes RP, Omay SB. Case Report: Suprasellar Pituitary Adenoma Presenting With Temporal Lobe Seizures. Frontiers In Surgery 2020, 7: 598138. PMID: 33335912, PMCID: PMC7736041, DOI: 10.3389/fsurg.2020.598138.Peer-Reviewed Case Reports and Technical NotesPituitary macroadenomaTemporal lobeFurther seizure activityTemporal lobe seizuresYear old maleMass effectLeft temporal lobeSuprasellar pituitary adenomasEndocrine dysfunctionGeneralized seizuresSeizure activityPituitary pathologyPituitary adenomasMedical treatmentSeizuresEndoscopic endonasalMacroadenomasLobePatientsDysfunctionAdenomasSymptomsTumorsEndonasalPathology
2013
139 Brain Extracellular Branched-Chain Amino Acids in Medically Refractory Localization-Related Epilepsy
Ong C, Damisah E, Haldeman C, Eid T, Spencer D. 139 Brain Extracellular Branched-Chain Amino Acids in Medically Refractory Localization-Related Epilepsy. Neurosurgery 2013, 60: 166. DOI: 10.1227/01.neu.0000432730.18532.a2.Peer-Reviewed Original ResearchLocalization-related epilepsyRefractory localization-related epilepsyBrain areasExtracellular brain glutamateRatio of BCAAExcitatory transmitter glutamateInitiation of seizuresEpileptogenic brain areasCentral nervous systemBranched-chain amino acidsRefractory LocalizationMicrodialysis catheterIntracerebral microdialysisExtracellular glutamateBrain glutamateTransmitter glutamateElectrode implantationTherapeutic targetNervous systemExtracellular levelsSeizuresEpilepsyBrain regionsDepth electrodesBCAA