2014
5-Aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy
Dhaher R, Damisah EC, Wang H, Gruenbaum SE, Ong C, Zaveri HP, Gruenbaum BF, Eid T. 5-Aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. Neurobiology Of Disease 2014, 67: 18-23. PMID: 24632421, PMCID: PMC4035438, DOI: 10.1016/j.nbd.2014.03.006.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyNumber of seizuresLobe epilepsyHippocampal formationMesial temporal lobe seizuresSevere typeEntorhinal-hippocampal areaExpression of seizuresStages of seizuresTemporal lobe seizuresDorsal hippocampal formationLocalization-related epilepsyMale Sprague-DawleyPotential therapeutic targetSeizure frequencyAlzet pumpsRacine scaleSevere seizuresSecond surgerySprague-DawleyPump placementMethionine sulfoximineGlutamine-glutamateTherapeutic target
2013
139 Brain Extracellular Branched-Chain Amino Acids in Medically Refractory Localization-Related Epilepsy
Ong C, Damisah E, Haldeman C, Eid T, Spencer D. 139 Brain Extracellular Branched-Chain Amino Acids in Medically Refractory Localization-Related Epilepsy. Neurosurgery 2013, 60: 166. DOI: 10.1227/01.neu.0000432730.18532.a2.Peer-Reviewed Original ResearchLocalization-related epilepsyRefractory localization-related epilepsyBrain areasExtracellular brain glutamateRatio of BCAAExcitatory transmitter glutamateInitiation of seizuresEpileptogenic brain areasCentral nervous systemBranched-chain amino acidsRefractory LocalizationMicrodialysis catheterIntracerebral microdialysisExtracellular glutamateBrain glutamateTransmitter glutamateElectrode implantationTherapeutic targetNervous systemExtracellular levelsSeizuresEpilepsyBrain regionsDepth electrodesBCAA