Cerebrospinal fluid untargeted metabolomic profiling of aneurysmal subarachnoid hemorrhage: an exploratory study
Lu AY, Damisah EC, Winkler EA, Grant RA, Eid T, Bulsara KR. Cerebrospinal fluid untargeted metabolomic profiling of aneurysmal subarachnoid hemorrhage: an exploratory study. British Journal Of Neurosurgery 2018, 32: 637-641. PMID: 30585503, DOI: 10.1080/02688697.2018.1519107.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageGlasgow Outcome ScaleLong-term outcomesASAH patientsSubarachnoid hemorrhageTime pointsCSF samplesHigh-grade aSAH patientsFisher grade 4Cerebrospinal fluid samplesFalse discovery rate correctionSpecific metabolite changesLow disabilitySurgical therapyClinical outcomesCSF metabolitesUntargeted metabolomic profilingOutcome ScaleTissue hypoxiaGrade 3Year postPatientsClinical settingMetabolite predictorsMetabolic changes