2018
Imaging the Effects of &bgr;-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism
Bazzigaluppi P, Lake EM, Beckett TL, Koletar MM, Weisspapir I, Heinen S, Mester J, Lai A, Janik R, Dorr A, McLaurin J, Stanisz GJ, Carlen PL, Stefanovic B. Imaging the Effects of &bgr;-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism. Stroke 2018, 49: 2173-2181. PMID: 30354983, DOI: 10.1161/strokeaha.118.020586.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxybutyric AcidAcetoacetatesAnimalsAstrocytesBlood GlucoseBrainBrain IschemiaCell DeathCerebrovascular CirculationDisease Models, AnimalElectrophysiological PhenomenaEndothelin-1HemodynamicsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMicroinjectionsNeuronsRatsReactive Oxygen SpeciesSensorimotor CortexConceptsBody β-hydroxybutyrateFunctional recoveryMagnetic resonance imagingIschemic insultNeuronal deathResonance imagingFocal cortical strokeVehicle-administered animalsNeurological deficit scoresKetone body β-hydroxybutyrateNeuronal glucose uptakeContinuous arterial spinReduced oxidative stressPurpose Recent evidenceReactive oxygen species productionCortical microinjectionsCortical strokePostischemic hyperglycemiaDeficit scoresNeurovascular functionAcute phaseCerebrovascular reactivitySensorimotor cortexCerebral hemodynamicsEndothelin-1
2017
Reduced Cerebrovascular Reactivity and Increased Resting Cerebral Perfusion in Rats Exposed to a Cafeteria Diet
Gomez-Smith M, Janik R, Adams C, Lake EM, Thomason LAM, Jeffers MS, Stefanovic B, Corbett D. Reduced Cerebrovascular Reactivity and Increased Resting Cerebral Perfusion in Rats Exposed to a Cafeteria Diet. Neuroscience 2017, 371: 166-177. PMID: 29229555, DOI: 10.1016/j.neuroscience.2017.11.054.Peer-Reviewed Original ResearchConceptsRat endothelial cell antigen-1Cerebrovascular reactivityCafeteria dietMagnetic resonance imagingCerebral perfusionStandard chowAnimals fed standard chowEndothelial cell antigen-1Arterial spin labeling magnetic resonance imagingContinuous arterial spin labeling (CASL) magnetic resonance imagingEndothelin-1 injectionReduced Cerebrovascular ReactivityUltra-processed dietFed standard chowSprague-Dawley ratsShort-term consumptionCell antigen-1CAF ratsCerebrovascular functionIschemic lesionsCerebral microvasculatureDiet ratsSensorimotor cortexBrain perfusionDawley rats