2022
Obsessional slowness in obsessive-compulsive disorder: identifying characteristics and comorbidities in a clinical sample
Crowe E, Rosário M, Ferrão Y, Albertella L, Miguel E, Fontenelle L. Obsessional slowness in obsessive-compulsive disorder: identifying characteristics and comorbidities in a clinical sample. International Journal Of Psychiatry In Clinical Practice 2022, 27: 161-170. PMID: 36409661, DOI: 10.1080/13651501.2022.2147441.Peer-Reviewed Original ResearchThe Phenomenology of Obsessive–Compulsive Symptoms in Tourette Syndrome
Ferrão Y, de Alvarenga P, Hounie A, de Mathis M, Farhat L, do Rosário M, Miguel E. The Phenomenology of Obsessive–Compulsive Symptoms in Tourette Syndrome. 2022, 45-64. DOI: 10.1093/med/9780197543214.003.0004.Peer-Reviewed Original ResearchTourette syndromeObsessive-compulsive disorderObsessive-compulsive symptomsComorbid obsessive-compulsive disorderPost-traumatic stress disorderAttention-deficit/hyperactivity disorderPsychiatric comorbidityBasal gangliaBehavioral comorbiditiesSeparation anxiety disorderTreatment approachesClinical practiceComorbid diagnosesSymptom presentationComorbiditiesSimple phobiaStress disorderAnxiety disordersHyperactivity disorderSymptomsDisordersGenetic vulnerabilityBehavioral problemsSyndrome
2021
Association Between Obsessive-Compulsive Symptom Dimensions in Mothers and Psychopathology in Their Children
Blanco-Vieira T, Hoexter M, Batistuzzo M, Alvarenga P, Szejko N, Fumo A, Miguel E, do Rosário M. Association Between Obsessive-Compulsive Symptom Dimensions in Mothers and Psychopathology in Their Children. Frontiers In Psychiatry 2021, 12: 674261. PMID: 34262490, PMCID: PMC8273307, DOI: 10.3389/fpsyt.2021.674261.Peer-Reviewed Original ResearchPresence of OCSObsessive-compulsive symptomsChild Behavior ChecklistMini-International Psychiatric InterviewPsychopathology statusSymptom dimensionsBehavioral problemsNon-clinical presentationsYale-Brown ObsessiveAggression/violenceClinical variablesOverall prevalenceSchool-aged childrenPsychiatric interviewMaternal psychopathologyMother-child dyadsDimensional Yale-Brown ObsessiveSubscale scoresOwn psychopathologyMothersBehavior ChecklistMultiple regression analysisSignificant correlationRegression analysis
2020
Stressful Life Events and the Clinical Expression of Obsessive–Compulsive Disorder (OCD): An Exploratory Study
Imthon A, Caldart C, do Rosário M, Fontenelle L, Miguel E, Ferrão Y. Stressful Life Events and the Clinical Expression of Obsessive–Compulsive Disorder (OCD): An Exploratory Study. Journal Of Clinical Medicine 2020, 9: 3371. PMID: 33096706, PMCID: PMC7590000, DOI: 10.3390/jcm9103371.Peer-Reviewed Original ResearchStressful life eventsObsessive-compulsive disorderPost-traumatic stress disorderOCD patientsOccurrence of SLEsNonwhite skin colorLife eventsLogistic regression variablesCross-sectional studySensory phenomenaYale-Brown ObsessiveClinical characteristicsClinical expressionPsychiatric disordersHistory questionnairePatientsObsessive-compulsive symptomsStress disorderCompulsive ScaleDimensional Yale-Brown ObsessiveStatistical significanceDisordersPositive associationOCD symptomsSymptomsDelayed Brain Cyst Formation After Gamma Knife Anterior Capsulotomy
Kasabkojian S, Dwan A, Maziero M, de Salles A, Gorgulho A, Miguel E, Fillipo de Queiroz Vattimo E, Lopes A. Delayed Brain Cyst Formation After Gamma Knife Anterior Capsulotomy. World Neurosurgery 2020, 145: 298-300. PMID: 33022431, DOI: 10.1016/j.wneu.2020.07.199.Peer-Reviewed Original ResearchConceptsRefractory obsessive-compulsive disorderAnterior capsulotomyObsessive-compulsive disorderBrain cyst formationFrontal lobe symptomsMagnetic resonance imagingAnterior frontal regionsPostoperative monthBrain cystsBrain edemaManic episodesVisual hallucinationsRadiosurgical proceduresAbnormal complicationsHigh dosesCapsulotomyResonance imagingObsessive-compulsive symptomsCyst formationEffective optionLeft hemisphereRight hemisphereFrontal regionsComplicationsSymptomsSocial losses predict a faster onset and greater severity of obsessive-compulsive disorder
Destrée L, Albertella L, Torres A, Ferrão Y, Shavitt R, Miguel E, Fontenelle L. Social losses predict a faster onset and greater severity of obsessive-compulsive disorder. Journal Of Psychiatric Research 2020, 130: 187-193. PMID: 32828024, DOI: 10.1016/j.jpsychires.2020.07.027.Peer-Reviewed Original ResearchConceptsClinical obsessive-compulsive disorderObsessive-compulsive disorderStressful life eventsSpeed of progressionYale-Brown ObsessiveDSM-IV Axis I DisordersLife eventsCompulsive ScaleAxis I DisordersStructured Clinical InterviewSeverity of symptomsSymptom dimensionsBeck Depression InventorySubclinical obsessive-compulsive symptomsBeck Anxiety InventorySpecific obsessive-compulsive symptom dimensionsI disordersFaster onsetPsychiatric disordersHistory questionnaireBrown AssessmentClinical InterviewGreater severityDepression InventoryObsessive-compulsive symptomsCognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder
Bernardes E, Saraiva L, e Souza M, Hoexter M, Chacon P, Requena G, Miguel E, Shavitt R, Polanczyk G, Cappi C, Batistuzzo M. Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder. BMC Psychiatry 2020, 20: 380. PMID: 32690046, PMCID: PMC7370498, DOI: 10.1186/s12888-020-02751-5.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive symptomsNeurocognitive domainsPediatric obsessive-compulsive disorderNon-verbal memoryProcessing speed domainCognitive domain analysisComprehensive neuropsychological batteryNon-clinical sampleYale-Brown ObsessiveSubdomain analysisVisuospatial memoryCognitive domainsExecutive functionVisuoconstructive abilitiesVisuoconstructive tasksCognitive performanceNeuropsychological variablesNeuropsychological batteryStructured Clinical InterviewProcessing speedNeurocognitive assessmentSpeed domainOCS severityCompulsive ScaleRisk factors for obsessive–compulsive symptoms. Follow-up of a community-based youth cohort
Macul Ferreira de Barros P, do Rosário MC, Szejko N, Polga N, Requena GL, Ravagnani B, Fatori D, Batistuzzo MC, Hoexter MQ, Rohde LA, Polanczyk GV, Leckman JF, Miguel EC, de Alvarenga PG. Risk factors for obsessive–compulsive symptoms. Follow-up of a community-based youth cohort. European Child & Adolescent Psychiatry 2020, 30: 89-104. PMID: 32076869, DOI: 10.1007/s00787-020-01495-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsRisk factorsAbsence of breastfeedingOCS scoresBaseline anxiety disordersPotential risk factorsLarge community cohortLow socioeconomic statusRegression analysisMental health assessmentMaternal stress levelsLower intelligence quotientCommunity cohortChildhood adversityLower ageHigher OCS scoresAnxiety disordersPsychopathological factorsSocioeconomic statusGenetic factorsSignificant predictorsBaselineHealth assessmentScoresAge
2019
F36. Obsessive-Compulsive symptoms, Polygenic Risk Score and Thalamic Development in Children From the Brazilian High-Risk Cohort Study
Ravagnani B, Hoexter M, Santoro M, Leckman J, Pan P, Salum G, Jackowski A, Hampson M, do Rosário M, Belangero S, Alvarenga P, de Barros P, Miguel E, Zugman A. F36. Obsessive-Compulsive symptoms, Polygenic Risk Score and Thalamic Development in Children From the Brazilian High-Risk Cohort Study. Biological Psychiatry 2019, 85: s226. DOI: 10.1016/j.biopsych.2019.03.573.Peer-Reviewed Original ResearchHigh Risk Cohort StudyCohort studyPolygenic risk scoresRisk scoreThalamic developmentObsessive-compulsive symptomsSymptoms
2018
Obsessive-compulsive symptoms in children with first degree relatives diagnosed with obsessive-compulsive disorder
Chacon P, Bernardes E, Faggian L, Batistuzzo M, Moriyama T, Miguel E, Polanczyk G. Obsessive-compulsive symptoms in children with first degree relatives diagnosed with obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2018, 40: 388-393. PMID: 29898190, PMCID: PMC6899383, DOI: 10.1590/1516-4446-2017-2321.Peer-Reviewed Original ResearchConceptsPresence of OCSObsessive-compulsive disorderFirst-degree relativesObsessive-compulsive symptomsSocioeconomic statusImportant risk factorLow socioeconomic statusFuture longitudinal studiesClinical correlatesAssessed childrenRisk factorsDegree relativesFamily historySymptomsContamination/Longitudinal studyOCD diagnosisDisordersChildrenHigh rateFamily membersChildhoodCorrelatesStatus
2017
Low frequency fluctuation of brain spontaneous activity and obsessive-compulsive symptoms in a large school-age sample
Hoexter M, Biazoli C, Alvarenga P, Batistuzzo M, Salum G, Gadelha A, Pan P, Anés M, Mancini-Martins L, Moura L, Soriano-Mas C, Aquilla M, Amaro E, Rohde L, Jackowski A, Bressan R, Miguel E, do Rosario M, Sato J. Low frequency fluctuation of brain spontaneous activity and obsessive-compulsive symptoms in a large school-age sample. Journal Of Psychiatric Research 2017, 96: 224-230. PMID: 29102817, DOI: 10.1016/j.jpsychires.2017.10.009.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsBrain spontaneous activityLow-frequency fluctuationsSpontaneous activityRight sensorimotor cortexHigh Risk Cohort StudyState functional magnetic resonance imaging (rs-fMRI) dataSpontaneous activity changesPredictors of riskWell-Being AssessmentSpontaneous brain activitySuperior temporal cortexSuperior temporal gyrusCohort studyObsessive-compulsive disorderSensorimotor cortexMagnetic resonance imaging dataPsychiatric disordersOverall psychopathologyTemporal gyrusFractional amplitudeGeneral linear modelFunctional magnetic resonance imaging (fMRI) dataCompulsive symptomsBrain activityThe Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children
Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG. The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 342-348. PMID: 28151703, PMCID: PMC5439443, DOI: 10.1089/cap.2016.0125.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsPsychiatric comorbidityPredictive valueBehavioral problemsDSM-IV psychiatric diagnosesPresence of OCSGroup of patientsHigh-risk cohortSignificant obsessive-compulsive symptomsNegative predictive valuePositive predictive valueHigh rateSeverity of OCSRisk cohortSchool-Aged ChildrenDepressive disorderFunctional impairmentPsychiatric diagnosisChild Behavior ChecklistComorbiditiesSevere psychopathologyBeing AssessmentScreening toolPediatric OCDAnxiety disorders
2014
P2‐139: NEURONAL DENSITY REDUCTION IN BRAINS OF ELDERLY PEOPLE AFFECTED BY OBSESSIVE‐COMPULSIVE SYMPTOMS
de Oliveira K, Grinberg L, Lafer B, Nery F, Hoexter M, Lima L, Di Lorenzo Alho A, Farfel J, Suemoto C, Gigante A, de Lucena Ferretti‐Rebusttini R, Leite R, Neves R, Nascimento C, da Silva A, Brentani H, Nitrini R, Miguel E, Jacob‐Filho W, Heinsen H, Pasqualucci C. P2‐139: NEURONAL DENSITY REDUCTION IN BRAINS OF ELDERLY PEOPLE AFFECTED BY OBSESSIVE‐COMPULSIVE SYMPTOMS. Alzheimer's & Dementia 2014, 10: p521-p522. DOI: 10.1016/j.jalz.2014.05.814.Peer-Reviewed Original ResearchExaggerating, mislabeling or simulating obsessive–compulsive symptoms: Case reports of patients claiming to have obsessive–compulsive disorder
Fontenelle L, Lins-Martins N, Melca I, Lima A, de Menezes G, Torres A, Yücel M, Miguel E, Mendlowicz M. Exaggerating, mislabeling or simulating obsessive–compulsive symptoms: Case reports of patients claiming to have obsessive–compulsive disorder. Comprehensive Psychiatry 2014, 55: 1188-1194. PMID: 24794641, DOI: 10.1016/j.comppsych.2014.03.023.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderDrug-related side effectsAxis I psychiatric disordersNon-consecutive patientsDisease courseCase reportTreatment responsePsychiatric disordersReported casesSide effectsSymptom patternsClinical judgmentOCD clinicPatientsExperienced cliniciansObsessive-compulsive symptomsPattern of responseFormal diagnosisSymptomsDiagnosisOCD diagnosisCompulsive symptomsDisordersClinicClinical vignettesSearching for the Immune Basis of Obsessive-Compulsive Disorder
Teixeira AL, Rodrigues DH, Marques AH, Miguel EC, Fontenelle LF. Searching for the Immune Basis of Obsessive-Compulsive Disorder. NeuroImmunoModulation 2014, 21: 152-158. PMID: 24557049, DOI: 10.1159/000356554.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderImmune parametersAnti-basal ganglia antibodiesParticular immune profileRheumatic feverImmune profileComorbid conditionsImmune basisAutoimmune diseasesImmune cellsPsychotropic drugsClinical observationsObsessive-compulsive symptomsPatientsUnequivocal changesOCD patientsElevated frequencyDisordersFeverEtiopathogenesisCytokinesSymptomsDiseaseAntibodies
2013
Late-onset obsessive-compulsive disorder: Risk factors and correlates
Frydman I, do Brasil PE, Torres AR, Shavitt RG, Ferrão YA, Rosário MC, Miguel EC, Fontenelle LF. Late-onset obsessive-compulsive disorder: Risk factors and correlates. Journal Of Psychiatric Research 2013, 49: 68-74. PMID: 24267559, DOI: 10.1016/j.jpsychires.2013.10.021.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderLate-onset obsessive-compulsive disorderSubclinical obsessive-compulsive symptomsPosttraumatic stress disorderObsessive-compulsive symptomsOnset obsessive-compulsive disorderObsessive-compulsive spectrum disordersMajor traumatic eventEarly-onset obsessive-compulsive disorderBrazilian Research ConsortiumTraumatic eventsSpectrum disorderStress disorderOCD symptomsOCD onsetDearth of studiesSelfCorrelatesDisordersPotential variablesNeural networkDistressSymptomsSizeable proportionSeries of modelsThe Phenomenology of Obsessive-Compulsive Symptoms in Tourette Syndrome
FerrãO Y, De Alvarenga P, Hounie A, De Mathis M, De RosáRio M, Miguel E. The Phenomenology of Obsessive-Compulsive Symptoms in Tourette Syndrome. 2013, 50-73. DOI: 10.1093/med/9780199796267.003.0003.Peer-Reviewed Original ResearchObsessive-compulsive disorderTourette syndromeObsessive-compulsive symptomsComorbid obsessive-compulsive disorderAttention-deficit/hyperactivity disorderPosttraumatic stress disorderPsychiatric comorbidityBehavioral comorbiditiesSeparation anxiety disorderClinical practiceComorbid diagnosesComorbiditiesSymptomsSimple phobiaStress disorderAnxiety disordersHyperactivity disorderDisordersSyndromeBehavioral problems
2011
Towards a post-traumatic subtype of obsessive–compulsive disorder
Fontenelle L, Cocchi L, Harrison B, Shavitt R, do Rosário M, Ferrão Y, de Mathis M, Cordioli A, Yücel M, Pantelis C, de Jesus Mari J, Miguel E, Torres A. Towards a post-traumatic subtype of obsessive–compulsive disorder. Journal Of Anxiety Disorders 2011, 26: 377-383. PMID: 22230220, DOI: 10.1016/j.janxdis.2011.12.001.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive symptomsOCD patientsPost-traumatic stress disorderOnset of OCDCompulsive buying disorderHistory of PTSDTraumatic eventsStress disorderBuying disorderOCD onsetPanic disorderPTSDAlcohol-related disordersClinical featuresDisordersEducational levelMultinomial logistic regression analysisLogistic regression analysisSuicide planEarly ageLow educational levelMiscellaneous symptomsLater ageRegression analysisRole of stressful and traumatic life events in obsessive–compulsive disorder
Fontenelle L, Cocchi L, Harrison B, Miguel E, Torres A. Role of stressful and traumatic life events in obsessive–compulsive disorder. Neuropsychiatry 2011, 1: 61-69. DOI: 10.2217/npy.10.1.Peer-Reviewed Original ResearchCognitive Dysfunction in Post-Traumatic Obsessive–Compulsive Disorder
Borges M, Braga D, Iêgo S, D'Alcante C, Sidrim I, Machado M, Pinto P, Cordioli A, do Rosário M, Petribú K, Mendlowicz M, Mari J, Miguel E, Fontenelle L. Cognitive Dysfunction in Post-Traumatic Obsessive–Compulsive Disorder. Australian & New Zealand Journal Of Psychiatry 2011, 45: 76-85. PMID: 21174503, DOI: 10.3109/00048674.2010.527822.Peer-Reviewed Original ResearchConceptsSet-shifting abilityObsessive-compulsive disorderPoor set-shifting abilitiesWechsler Memory Scale-Logical MemoryBrief Visual Memory TestWisconsin Card Sorting TestVisual memory testsIowa Gambling TaskCard Sorting TestFollowing neuropsychological testsWechsler Abbreviated ScaleTypes of OCDPosttraumatic stress disorderObsessive-compulsive symptomsMemory testVisuospatial memoryGambling TaskLogical memorySorting TestAbbreviated ScaleNeurocognitive patternsNeuropsychological testsStress disorderVisuospatial recognitionCompulsive disorder