2024
Childhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders
Machado V, Fonseca L, Barbosa M, Bressan R, Pan P, Rohde L, Miguel E, Salum G, Ziebold C, Gadelha A. Childhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders. Schizophrenia Bulletin Open 2024, 5: sgae003. PMID: 39144118, PMCID: PMC11207689, DOI: 10.1093/schizbullopen/sgae003.Peer-Reviewed Original ResearchBrazilian High-Risk CohortCross-lagged panel modelChildhood anxiety symptomsPsychotic experiencesAnxiety symptomsSubclinical psychotic symptomsContinuum of psychosisStandardized self-report questionnairesTime-lagged associationsCross-lagged effectsIncreased levels of anxietySelf-report questionnairesLevels of anxietyPsychosis pronenessPsychotic symptomsPsychiatric disordersSymptom domainsMental illnessAnxietyHigh-risk cohortAnxiety scoresPsychosisAdolescentsPE scoresPanel model
2023
The association between duration of breastfeeding and the trajectory of brain development from childhood to young adulthood: an 8-year longitudinal study
Grevet L, Teixeira D, Pan P, Jackowski A, Zugman A, Miguel E, Rohde L, Salum G. The association between duration of breastfeeding and the trajectory of brain development from childhood to young adulthood: an 8-year longitudinal study. European Child & Adolescent Psychiatry 2023, 33: 1863-1873. PMID: 37650992, DOI: 10.1007/s00787-023-02283-9.Peer-Reviewed Original ResearchOverall cortical thicknessDuration of breastfeedingTotal intracranial volumeCortical thicknessBrain developmentIntracranial volumeLong-term health benefitsHealth benefitsHigh-risk cohortTotal brain volumeGlobal cortical thicknessStructural brain developmentMental health benefitsMultiple confoundersCortical areasMRI scansBrain areasBrain volumeBreastfeedingMRI T1Time pointsBrain measuresEarly adulthoodYoung adulthoodLongitudinal studyLongitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us?
Barbosa M, Machado V, Ziebold C, Moriyama T, Bressan R, Pan P, Rohde L, Miguel E, Fonseca L, Van Os J, Gadelha A. Longitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us? Schizophrenia Research 2023, 255: 33-40. PMID: 36958268, DOI: 10.1016/j.schres.2023.03.003.Peer-Reviewed Original ResearchConceptsPsychotic experiencesTime pointsHigh-risk cohortPrevious systematic reviewDifferent age groupsDifferent time pointsBaseline evaluationLifetime psychotic experiencesPositive symptomsSystematic reviewAge groupsPerceptual abnormalitiesLongitudinal studyBrazilian High-Risk CohortPsychosis pronenessGood model fit indicesThree-factor solutionChildrenIdentifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample
Cunha G, Caye A, Pan P, Fisher H, Pereira R, Ziebold C, Bressan R, Miguel E, Salum G, Rohde L, Kohrt B, Mondelli V, Kieling C, Gadelha A. Identifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample. Brazilian Journal Of Psychiatry 2023, 45: 242-248. PMID: 37126861, PMCID: PMC10288471, DOI: 10.1590/1516-4446-2022-2775.Peer-Reviewed Original Research
2022
The influence of caregiver attitudes and socioeconomic group on formal and informal mental health service use among youth
Paula C, Ziebold C, Ribeiro W, Pan P, Mari J, Bressan R, Miguel E, Rohde L, Salum G, Evans-Lacko S. The influence of caregiver attitudes and socioeconomic group on formal and informal mental health service use among youth. European Psychiatry 2022, 65: e34. PMID: 35684952, PMCID: PMC9251818, DOI: 10.1192/j.eurpsy.2022.24.Peer-Reviewed Original ResearchConceptsMental health careCare utilizationTreatment accessService useMental health service useMental health care utilizationParental stigmaMental healthHigh-risk cohortHealth care utilizationHealth service useHealth careLow socioeconomic classMental health conditionsType of careLogistic regression modelsLow-resource settingsInformal careMental health supportFacilitators/barriersYouth mental healthFormal service useHigher oddsCaregiver characteristicsCaregiver attitudes
2021
Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action
Terra T, Schafer J, Pan P, Costa A, Caye A, Gadelha A, Miguel E, Bressan R, Rohde L, Salum G. Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action. Journal Of Affective Disorders 2021, 298: 190-193. PMID: 34715179, DOI: 10.1016/j.jad.2021.10.108.Peer-Reviewed Original ResearchConceptsAsexual youthMental disordersWell-Being Behavior AssessmentHigh-risk cohortMental health conditionsPost-traumatic stress disorderAttention deficit hyperactivity disorderMental health problemsDeficit hyperactivity disorderMental health disparitiesStressful life eventsDepressive disorderPsychiatric disordersPrevalence estimatesHealth problemsConfidential questionnaireHealth disparitiesLogistic regressionStress disorderAnxiety disordersHealth conditionsConduct disorderGroup comparisonsHyperactivity disorderDisordersPredictors of gaming disorder in children and adolescents: a school-based study
Ferreira F, Bambini B, Tonsig G, Fonseca L, Picon F, Pan P, Salum G, Jackowski A, Miguel E, Rohde L, Bressan R, Gadelha A. Predictors of gaming disorder in children and adolescents: a school-based study. Brazilian Journal Of Psychiatry 2021, 43: 289-292. PMID: 32756806, PMCID: PMC8136393, DOI: 10.1590/1516-4446-2020-0964.Peer-Reviewed Original ResearchConceptsMental disordersWell-Being Behavior AssessmentHigh-risk cohortLogistic regression modelsSchool-based studyGaming disorderPsychiatric disordersUnhealthy patternsDisorder ratesSchool-based sampleDisordersSignificant predictorsFurther riskBrazilian High-Risk CohortCommunity sampleHigh rateBehavior changeMore hoursRegression modelsChildrenPredictorsAdolescentsHoursBehavior assessmentPattern variables
2019
SA72 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS
Spindola L, Santoro M, Pan P, Talarico F, Xavier G, Carvalho C, Gadelha A, Salum G, Miguel E, Rohde L, Zanardo E, Kulikowski L, Bressan R, Ota V, Belangero S. SA72 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2019, 29: s861. DOI: 10.1016/j.euroneuro.2017.08.144.Peer-Reviewed Original ResearchHigh-risk cohortPsychiatric disordersHealthy controlsGene expression profilingChild Behavior ChecklistEarly-onset psychiatric disordersBlood of adolescentsPrevious psychiatric disorderBlood gene expression profilingCross-sectional studyOnset psychiatric disordersWell-Being AssessmentAttention deficit hyperactivity disorderMost psychiatric disordersCanonical pathwaysSchool-based studyLarge public healthExpression profilingDeficit hyperactivity disorderRisk cohortPrevalent diagnosisPD groupMajor depressionHC groupMultiple comparison correctionSU73 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS
Spindola L, Santoro M, Pan P, Talarico F, Xavier G, Carvalho C, Gadelha A, Salum G, Miguel E, Rohde L, Zanardo E, Kulikowski L, Bressan R, Ota V, Belangero S. SU73 GENE EXPRESSION IN BLOOD OF ADOLESCENTS WITH PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2019, 29: s927-s928. DOI: 10.1016/j.euroneuro.2017.08.262.Peer-Reviewed Original ResearchHigh-risk cohortPsychiatric disordersHealthy controlsGene expression profilingChild Behavior ChecklistEarly-onset psychiatric disordersBlood of adolescentsPrevious psychiatric disorderBlood gene expression profilingCross-sectional studyOnset psychiatric disordersWell-Being AssessmentAttention deficit hyperactivity disorderMost psychiatric disordersCanonical pathwaysSchool-based studyLarge public healthExpression profilingDeficit hyperactivity disorderRisk cohortPrevalent diagnosisPD groupMajor depressionHC groupMultiple comparison correction
2018
Effect of male-specific childhood trauma on telomere length
Xavier G, Spindola L, Ota V, Carvalho C, Maurya P, Tempaku P, Moretti P, Mazotti D, Sato J, Brietzke E, Miguel E, Grassi-Oliveira R, Mari J, Bressan R, Gadelha A, Pan P, Belangero S. Effect of male-specific childhood trauma on telomere length. Journal Of Psychiatric Research 2018, 107: 104-109. PMID: 30384090, DOI: 10.1016/j.jpsychires.2018.10.012.Peer-Reviewed Original ResearchConceptsHigh-risk cohortTelomere lengthImportant risk factorCross-sectional studyChild maltreatmentEarly life stressChild Behavior Checklist scoresSchool-based studySerious lifelong consequencesQuantitative polymerase chain reactionHistory of CMPolymerase chain reactionRisk factorsPsychiatric symptomsPsychiatric disordersMultiplex quantitative polymerase chain reactionLifelong consequencesBlood cellsChildhood traumaCM scoreLife stressChain reactionSexBrazilian High-Risk CohortShort telomeresF168. PSYCHOTIC EXPERIENCE AND ADOLESCENT BRAIN TRAJECTORY: EVIDENCE FOR STRUCTURAL ALTERATIONS IN DOPAMINERGIC REGIONS
Zugman A, Gadelha A, Argolo F, Pan P, Rohde L, Miguel E, Bressan R, Jackowski A. F168. PSYCHOTIC EXPERIENCE AND ADOLESCENT BRAIN TRAJECTORY: EVIDENCE FOR STRUCTURAL ALTERATIONS IN DOPAMINERGIC REGIONS. Schizophrenia Bulletin 2018, 44: s286-s286. PMCID: PMC5888229, DOI: 10.1093/schbul/sby017.699.Peer-Reviewed Original ResearchCortical thickness measuresMental disordersCortical thicknessPsychotic experiencesSubcortical volumesLower subcortical volumesHigh-risk cohortCurrent psychiatric diagnosisPathogenesis of schizophreniaCurrent psychotic disorderAge interaction termMultiple comparisonsMulti-site longitudinal studyCommunity cohortDopaminergic neurotransmissionSubsequent riskDopaminergic imbalanceRight putamenBrain developmental trajectoriesMRI scansPsychiatric diagnosisPsychotic disordersBaseline assessmentCaudateAdolescent brain
2017
The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children
Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG. The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 342-348. PMID: 28151703, PMCID: PMC5439443, DOI: 10.1089/cap.2016.0125.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsPsychiatric comorbidityPredictive valueBehavioral problemsDSM-IV psychiatric diagnosesPresence of OCSGroup of patientsHigh-risk cohortSignificant obsessive-compulsive symptomsNegative predictive valuePositive predictive valueHigh rateSeverity of OCSRisk cohortSchool-Aged ChildrenDepressive disorderFunctional impairmentPsychiatric diagnosisChild Behavior ChecklistComorbiditiesSevere psychopathologyBeing AssessmentScreening toolPediatric OCDAnxiety disorders